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Table 1 A partial list of proteins overexpressed in TBM

From: Quantitative proteomics for identifying biomarkers for tuberculous meningitis

  Gene Symbol Protein Description Fold-change
1 WARS Tryptophanyl-tRNA synthetase, cytoplasmic isoform b It induced by interferon and involved in the catalyzation of the aminoacylation of tRNA (trp) with tryptophan. 7.2
2 SLC4A4 Electrogenic sodium bicarbonate cotransporter 1 isoform 2 It plays a functional role in the regulation of bicarbonate secretion and absorption and intracellular pH. 6.9
3 NPM1 Nucleophosmin isoform 3 It is a phosphoprotein which shuttles between the nucleus and the cytoplasm. It plays a role in ARF/p53 signaling pathway. 4.8
4 DHX9 ATP-dependent RNA helicase A It localizes to cytoplasm and nucleus. It acts as a transcriptional regulator. 4.9
5 HPCA Neuron-specific calcium-binding protein hippocalcin It belongs to the neuron-specific calcium-binding proteins family. It may play a role in the neurons of the central nervous system. 4.4
6 GPM6A Neuronal membrane glycoprotein M6-a isoform 3 It is a transmembrane protein and expressed on neurons in the central nervous system. 3.8
7 GFAP Glial fibrillary acidic protein isoform 2 It is an intermediate filament protein and a marker for astrocytes. It is overexpressed in astrogliosis. 3.2
8 SLC8A2 Sodium/calcium exchanger 2 precursor It is a Sodium/calcium exchanger, regulates the intracellular calcium concentrations. 2.8
9 VIM Vimentin It belongs to the intermediate filament protein family. It plays a role in cell shape and integrity. 2.8
10 VGF VGF nerve growth factor inducible precursor It expressed in neuroendocrine cells and overexpressed by nerve growth factor 2.5