Table 1 A partial list of proteins overexpressed in TBM
From: Quantitative proteomics for identifying biomarkers for tuberculous meningitis
| Â | Gene Symbol | Protein | Description | Fold-change |
|---|---|---|---|---|
1 | WARS | Tryptophanyl-tRNA synthetase, cytoplasmic isoform b | It induced by interferon and involved in the catalyzation of the aminoacylation of tRNA (trp) with tryptophan. | 7.2 |
2 | SLC4A4 | Electrogenic sodium bicarbonate cotransporter 1 isoform 2 | It plays a functional role in the regulation of bicarbonate secretion and absorption and intracellular pH. | 6.9 |
3 | NPM1 | Nucleophosmin isoform 3 | It is a phosphoprotein which shuttles between the nucleus and the cytoplasm. It plays a role in ARF/p53 signaling pathway. | 4.8 |
4 | DHX9 | ATP-dependent RNA helicase A | It localizes to cytoplasm and nucleus. It acts as a transcriptional regulator. | 4.9 |
5 | HPCA | Neuron-specific calcium-binding protein hippocalcin | It belongs to the neuron-specific calcium-binding proteins family. It may play a role in the neurons of the central nervous system. | 4.4 |
6 | GPM6A | Neuronal membrane glycoprotein M6-a isoform 3 | It is a transmembrane protein and expressed on neurons in the central nervous system. | 3.8 |
7 | GFAP | Glial fibrillary acidic protein isoform 2 | It is an intermediate filament protein and a marker for astrocytes. It is overexpressed in astrogliosis. | 3.2 |
8 | SLC8A2 | Sodium/calcium exchanger 2 precursor | It is a Sodium/calcium exchanger, regulates the intracellular calcium concentrations. | 2.8 |
9 | VIM | Vimentin | It belongs to the intermediate filament protein family. It plays a role in cell shape and integrity. | 2.8 |
10 | VGF | VGF nerve growth factor inducible precursor | It expressed in neuroendocrine cells and overexpressed by nerve growth factor | 2.5 |