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Table 2 A partial list of downregulated proteins in TBM

From: Quantitative proteomics for identifying biomarkers for tuberculous meningitis

  Gene Symbol Protein Description Fold-change
1 PDIA6 Protein disulfide-isomerase A6 precursor It is endoplasmic reticulum (ER) resident protein and it plays a role in folding of disulfide-bonded proteins 2.0
2 KPNA4 Importin subunit alpha-4 It is cytoplasmic protein, recognizes nuclear localization signals. 2.0
3 PFDN5 Prefoldin subunit 5 isoform alpha It belongs to the prefoldin alpha subunit family. It is a subunit of the molecular chaperone complex, involved in protein folding. 2.5
4 GARS Glycyl-tRNA synthetase It belongs to the class II family of tRNA synthetases and this protein plays a role in autoimmune diseases. 3.0
5 MDH1 Malate dehydrogenase, cytoplasmic It localized to the cytoplasm and mitochondria. It involved in malate-aspartate shuttle. 3.0
6 AK1 Adenylate kinase isoenzyme 1 It is an enzyme involved in regulating the adenine nucleotide composition in the cell and it is localized in the cytosol. 3.0
7 LANCL1 LanC-like protein 1 It is a loosely associated peripheral membrane protein which belongs to the LanC family of bacterial membrane-associated proteins. It plays a role in antimicrobial peptide synthesis. 5.0
8 SNCG Gamma-synuclein It belongs to the member of the synuclein family of proteins and it may play a role in the pathogenesis of neurodegenerative diseases. 5.0
9 PTPLB Protein-tyrosine phosphatase-like member B It localizes to endoplasmic reticulum (ER) and involved in the dehydration of very long chain fatty acid synthesis 7.0
10 NCDN Neurochondrin isoform 2 It is a cytoplasmic protein and may play a role in spatial learning processes. 7.0