Table 2 A partial list of downregulated proteins in TBM
From: Quantitative proteomics for identifying biomarkers for tuberculous meningitis
| Â | Gene Symbol | Protein | Description | Fold-change |
|---|---|---|---|---|
1 | PDIA6 | Protein disulfide-isomerase A6 precursor | It is endoplasmic reticulum (ER) resident protein and it plays a role in folding of disulfide-bonded proteins | 2.0 |
2 | KPNA4 | Importin subunit alpha-4 | It is cytoplasmic protein, recognizes nuclear localization signals. | 2.0 |
3 | PFDN5 | Prefoldin subunit 5 isoform alpha | It belongs to the prefoldin alpha subunit family. It is a subunit of the molecular chaperone complex, involved in protein folding. | 2.5 |
4 | GARS | Glycyl-tRNA synthetase | It belongs to the class II family of tRNA synthetases and this protein plays a role in autoimmune diseases. | 3.0 |
5 | MDH1 | Malate dehydrogenase, cytoplasmic | It localized to the cytoplasm and mitochondria. It involved in malate-aspartate shuttle. | 3.0 |
6 | AK1 | Adenylate kinase isoenzyme 1 | It is an enzyme involved in regulating the adenine nucleotide composition in the cell and it is localized in the cytosol. | 3.0 |
7 | LANCL1 | LanC-like protein 1 | It is a loosely associated peripheral membrane protein which belongs to the LanC family of bacterial membrane-associated proteins. It plays a role in antimicrobial peptide synthesis. | 5.0 |
8 | SNCG | Gamma-synuclein | It belongs to the member of the synuclein family of proteins and it may play a role in the pathogenesis of neurodegenerative diseases. | 5.0 |
9 | PTPLB | Protein-tyrosine phosphatase-like member B | It localizes to endoplasmic reticulum (ER) and involved in the dehydration of very long chain fatty acid synthesis | 7.0 |
10 | NCDN | Neurochondrin isoform 2 | It is a cytoplasmic protein and may play a role in spatial learning processes. | 7.0 |