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Table 2 Differential Protein List. Proteins of different level in the urine of ADPKD patients compared to healthy controls. Ratio is given as ADPKD/Control

From: Urine proteome of autosomal dominant polycystic kidney disease patients

no

protein

qvalue

ratio

peptides

description

1

P01019

0.00003

1.7

33

Angiotensinogen

2

P01008

0.00003

2.01

28

Antithrombin-III

3

P01023

0.00003

3.16

62

Alpha-2-macroglobulin

4

Q9NZP8

0.00003

0.59

23

Complement C1r subcomponent-like protein

5

Q93088

0.00003

0.55

23

Betaine--homocysteine S-methyltransferase 1

6

Q16769

0.00003

0.51

24

Glutaminyl-peptide cyclotransferase

7

P02753

0.00003

2.65

11

Retinol-binding protein 4

8

P19013

0.00003

0.3

16

Keratin, type II cytoskeletal 4

9

P19835

0.00003

0.54

27

Bile salt-activated lipase

10

P00746

0.00003

5.44

14

Complement factor D

11

P12109

0.00003

0.53

43

Collagen alpha-1(VI) chain

12

P33908

0.00003

0.48

25

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

13

Q8WZ75

0.00003

0.41

16

Roundabout homolog 4

14

P02774

0.00003

1.78

24

Vitamin D-binding protein

15

P43652

0.00003

1.7

20

Afamin

16

Q8N307

0.00003

0.44

9

Mucin-20

17

Q9HCU0

0.00003

0.52

15

Endosialin

18

P02787

0.00003

1.84

70

Serotransferrin

19

P07602

0.00003

2.74

23

Proactivator polypeptide

20

P02679

0.00003

2.89

9

Fibrinogen gamma chain

21

P02763

0.00003

1.94

45

Alpha-1-acid glycoprotein 1

22

P00915

0.00003

3.21

12

Carbonic anhydrase 1

23

P02675

0.00003

2.17

14

Fibrinogen beta chain

24

Q13867

0.00003

0.38

10

Bleomycin hydrolase

25

P19823

0.00003

1.77

26

Inter-alpha-trypsin inhibitor heavy chain H2

26

P02647

0.00003

3.89

26

Apolipoprotein A-I

27

Q5SZK8

0.00003

0.6

22

FRAS1-related extracellular matrix protein 2

28

Q16270

0.00003

0.45

13

Insulin-like growth factor-binding protein 7

29

P36955

0.00003

2.51

25

Pigment epithelium-derived factor

30

P06727

0.00003

4.19

39

Apolipoprotein A-IV

31

P01024

0.00003

2.45

94

Complement C3

32

P61769

0.00003

3.69

21

Beta-2-microglobulin

33

Q6EMK4

0.00003

0.46

26

Vasorin

34

P20930

0.00003

0.51

33

Filaggrin

35

P02768

0.00003

1.69

191

Serum albumin

36

P01009

0.00003

1.64

99

Alpha-1-antitrypsin

37

P04114

0.00003

3.34

14

Apolipoprotein B-100

38

P31944

0.00003

0.44

15

Caspase-14

39

P04264

0.00003

1.81

44

Keratin, type II cytoskeletal 1

40

P24592

0.00003

5.08

3

Insulin-like growth factor-binding protein 6

41

O00533

0.00003

0.51

17

Neural cell adhesion molecule L1-like protein

42

P01133

0.00003

0.59

78

Pro-epidermal growth factor

43

P04180

0.00003

0.56

16

Phosphatidylcholine-sterol acyltransferase

44

P0C0L5

0.00003

1.4

83

Complement C4-B

45

P02652

0.00003

1.92

12

Apolipoprotein A-II

46

P05154

0.00003

0.38

38

Plasma serine protease inhibitor

47

P00738

0.00003

2.21

26

Haptoglobin

48

P08582

0.00003

0.54

20

Melanotransferrin

49

P05546

0.00003

2.32

13

Heparin cofactor 2

50

Q9UBC9

0.00006

0.49

18

Small proline-rich protein 3

51

P15151

0.00008

0.55

19

Poliovirus receptor

52

P04196

0.00008

1.81

14

Histidine-rich glycoprotein

53

P02766

0.00008

1.88

11

Transthyretin

54

P05090

0.00013

0.46

12

Apolipoprotein D

55

Q8NBJ4

0.00023

0.52

14

Golgi membrane protein 1

56

P04746

0.00025

0.7

84

Pancreatic alpha-amylase

57

P39059

0.00029

0.64

17

Collagen alpha-1(XV) chain

58

Q9UN70

0.00038

0.6

17

Protocadherin gamma-C3

59

P08473

0.00049

0.59

27

Neprilysin

60

Q00887

0.00069

5.04

4

Pregnancy-specific beta-1-glycoprotein 9

61

P78380

0.00082

0.56

10

Oxidized low-density lipoprotein receptor 1

62

Q99574

0.00082

0.59

20

Neuroserpin

63

P02790

0.00083

1.56

41

Hemopexin

64

Q99972

0.00134

2.39

8

Myocilin

65

P19827

0.00134

1.39

13

Inter-alpha-trypsin inhibitor heavy chain H1

66

Q6V0I7

0.00142

0.51

14

Protocadherin Fat 4

67

P02144

0.00175

3.59

5

Myoglobin

68

P55287

0.0019

0.63

21

Cadherin-11

69

Q9UQ72

0.00203

5.92

3

Pregnancy-specific beta-1-glycoprotein 11

70

P55290

0.00212

0.67

25

Cadherin-13

71

Q8IYS5

0.00221

0.55

12

Osteoclast-associated immunoglobulin-like receptor

72

Q9H8L6

0.00255

0.58

12

Multimerin-2

73

Q9NY97

0.00271

0.44

6

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

74

O43505

0.0032

0.52

9

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

75

P08571

0.00376

0.64

23

Monocyte differentiation antigen CD14

76

Q15828

0.00399

1.85

10

Cystatin-M

77

Q8TF66

0.00411

0.46

6

Leucine-rich repeat-containing protein 15

78

P02538

0.00417

0.57

38

Keratin, type II cytoskeletal 6A

79

P40197

0.00467

0.46

6

Platelet glycoprotein V

80

P00751

0.00492

1.66

16

Complement factor B

81

Q9BRK3

0.0055

0.67

19

Matrix-remodeling-associated protein 8

82

Q14393

0.00553

0.56

10

Growth arrest-specific protein 6

83

Q13508

0.00569

2.49

11

Ecto-ADP-ribosyltransferase 3

84

Q8IUL8

0.00569

0.61

14

Cartilage intermediate layer protein 2

85

P22105

0.00569

0.75

58

Tenascin-X

86

P54710

0.00569

0.4

4

Sodium/potassium-transporting ATPase subunit gamma

87

P07737

0.00581

2.42

5

Profilin-1

88

Q12860

0.00584

0.69

27

Contactin-1

89

Q86UN3

0.00622

0.61

8

Reticulon-4 receptor-like 2

90

P50995

0.00632

0.59

11

Annexin A11

91

P11597

0.00632

0.51

7

Cholesteryl ester transfer protein

92

Q9BRK5

0.00684

0.58

8

45 kDa calcium-binding protein

93

P35555

0.00684

0.72

15

Fibrillin-1

94

P55285

0.007

0.59

11

Cadherin-6

95

O75223

0.0075

0.63

8

Gamma-glutamylcyclotransferase

96

O75368

0.00794

2.03

5

SH3 domain-binding glutamic acid-rich-like protein

97

P51654

0.008

0.57

12

Glypican-3

98

Q9UKU9

0.00801

0.61

10

Angiopoietin-related protein 2

99

O43155

0.00801

0.59

12

Leucine-rich repeat transmembrane protein FLRT2

100

P05451

0.00803

1.7

13

Lithostathine-1-alpha

101

P29622

0.00882

0.57

14

Kallistatin

102

P02751

0.01028

0.8

90

Fibronectin

103

P98160

0.01045

0.75

115

Basement membrane-specific heparan sulfate proteoglycan core protein

104

P01031

0.01113

1.9

8

Complement C5

105

P20774

0.01175

2.5

4

Mimecan

106

Q5IJ48

0.01317

0.51

7

Crumbs homolog 2

107

Q16661

0.01319

3.75

3

Guanylate cyclase activator 2B

108

P49221

0.01365

0.67

12

Protein-glutamine gamma-glutamyltransferase 4

109

P22792

0.01403

0.64

13

Carboxypeptidase N subunit 2

110

P16444

0.0143

0.66

25

Dipeptidase 1

111

P35052

0.01447

0.68

16

Glypican-1

112

O14498

0.0148

0.63

12

Immunoglobulin superfamily containing leucine-rich repeat protein

113

O94910

0.01483

0.6

8

Latrophilin-1

114

P02511

0.01487

0.49

6

Alpha-crystallin B chain

115

Q9NRX4

0.01598

0.68

10

14 kDa phosphohistidine phosphatase

116

Q9BY67

0.01829

0.68

26

Cell adhesion molecule 1

117

P19022

0.01885

0.65

21

Cadherin-2

118

P27169

0.01891

3.48

2

Serum paraoxonase/arylesterase 1

119

Q7Z5N4

0.01891

0.61

7

Protein sidekick-1

120

O00391

0.01951

0.72

33

Sulfhydryl oxidase 1

121

Q8TB96

0.01951

0.56

6

T-cell immunomodulatory protein

122

P08603

0.01953

1.65

11

Complement factor H

123

O75340

0.02011

0.56

6

Programmed cell death protein 6

124

Q8IZF2

0.02011

0.57

9

Probable G-protein coupled receptor 116

125

Q08174

0.02013

0.65

30

Protocadherin-1

126

Q9UGT4

0.02173

0.66

23

Sushi domain-containing protein 2

127

Q15223

0.02277

0.6

7

Poliovirus receptor-related protein 1

128

P09467

0.02277

0.75

17

Fructose-1,6-bisphosphatase 1

129

P10253

0.02277

0.75

108

Lysosomal alpha-glucosidase

130

P04745

0.02277

0.47

5

Alpha-amylase 1

131

P15144

0.0253

0.71

73

Aminopeptidase N

132

Q8N271

0.02628

0.65

14

Prominin-2

133

Q9HBB8

0.02658

0.6

11

Mucin and cadherin-like protein

134

P21266

0.02672

0.65

5

Glutathione S-transferase Mu 3

135

P30530

0.0298

0.62

16

Tyrosine-protein kinase receptor UFO

136

Q08554

0.03104

3.06

2

Desmocollin-1

137

P20472

0.03378

0.52

5

Parvalbumin alpha

138

P13598

0.03484

0.63

7

Intercellular adhesion molecule 2

139

P10643

0.03556

2.02

5

Complement component C7

140

P43121

0.03723

0.65

14

Cell surface glycoprotein MUC18

141

Q08380

0.03793

0.73

41

Galectin-3-binding protein

142

O75487

0.0383

0.72

9

Glypican-4

143

O75339

0.04059

0.49

5

Cartilage intermediate layer protein 1

144

P02649

0.04059

0.69

18

Apolipoprotein E

145

P34059

0.04062

0.73

17

N-acetylgalactosamine-6-sulfatase

146

P35318

0.04219

0.49

4

ADM

147

Q12794

0.04254

0.58

7

Hyaluronidase-1

148

A9Z1Y9

0.04254

2.01

3

Thymosin beta-4-like protein 6

149

O14773

0.04437

0.69

22

Tripeptidyl-peptidase 1

150

O75015

0.04588

0.6

9

Low affinity immunoglobulin gamma Fc region receptor III-B

151

P30711

0.04618

0.4

2

Glutathione S-transferase theta-1

152

Q14894

0.04647

0.62

6

Mu-crystallin homolog

153

O43895

0.04733

0.68

18

Xaa-Pro aminopeptidase 2

154

Q9NQS3

0.04733

0.59

10

Poliovirus receptor-related protein 3

155

P04792

0.04848

0.59

7

Heat shock protein beta-1