Figure 2From: The cerebrospinal fluid proteome in HIV infection: change associated with disease severityHierarchy of protein abundances in across samples. The CSF proteome profile reveals differences between HIV-infected (+) and HIV-uninfected (-) control samples, demonstrated by unsupervised hierarchical clustering of subjects' CSF proteomes based on Pearson's cross correlation coefficient. Cluster analysis leads to the segregation of HIV (+) and HIV(-) samples, with all HIV negative samples populating the cluster in the lower right corner of the heat map and in serial samples from individuals forming clusters seen as variably-sized red squares in the diagonal. Importantly, these results reveal that the differences between HIV (+) individuals were greater than the differences between serial samples within a single subject.Back to article page