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Table 4 Univariate and Multivariate analyses of clinicopathological factors influencing overall survival

From: Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue

Variable

Category

No. of patients

P value by log-rank test

HRa

95% CIb

P value by Cox proportional hazards

Gender

Male

62

0.1288

   
 

Female

34

    

Age

< 65

45

0.8967

   
 

≥ 65

51

    

Location

Head

73

0.8589

   
 

Body-Tail

23

    

Histological differentiation

Well

8

0.2069

   
 

Moderate + Poor

77

    

Tumor stage

T1 + T2

10

0.1996

   
 

T3 + T4

86

    

Nodal stage

N0

63

0.0039

2.20

1.33-3.80

0.0020

 

N1

33

    

NCCN criteria

Resectable

50

0.0339

1.40

0.90-2.21

0.1419

 

Borderline resectable

46

    

Preoperative CA19-9

< 37 U/mL

25

0.3444

   
 

≥ 37 U/mL

71

    

Postoperative CA19-9

< 37 U/mL

57

0.0082

1.92

1.21-3.04

0.0062

 

≥ 37 U/mL

39

    

Adjuvant chemotherapy

Gemcitabine

58

0.4201

   
 

Others

38

    

Nm23/NDPK-A status

Negative

23

0.0103

1.97

1.16-3.56

0.0110

 

Positive

73

    
  1. a Hazard ratio.
  2. b Confidence Interval.
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Clinical Proteomics

ISSN: 1559-0275