Serum biomarkers of Burkholderia mallei infection elucidated by proteomic imaging of skin and lung abscesses

Table 1 Relative abundance of specific host proteins from infected lung and skin tissues

		Diseased fold-change ¹
Description	General function	Accession	Lung	Skin
Calprotectin	Innate immunity	F6QJD8	+255	+
78 kDa glucose-regulated protein	Adaptive immunity	F7C3R1	+14	+
Alpha-1-acid glycoprotein 1	Acute phase protein	G7PRL2	+	+10
Alpha-1-antichymotrypsin	Acute phase protein	F6SL79	+	+8
C3 and PZP-like alpha-2- macroglobulin domain-containing protein 1	Inflammation induced	G7PYU9	+20	+256
Calreticulin (CRP55)	Calcium homeostasis	F7FMQ2	+67	+
Endoplasmin	Immune chaperone	F7EZT6	+10	+256
Erythrocyte band 7 integral membrane protein isoform a	Red blood cell protein	F7HP19	+255	+
Fibrinogen alpha chain	Clotting	F6UZ60	+25	+203
Hemoglobin alpha chain	Red blood cell protein	G7Q017	−20	+12
Hemoglobin subunit beta	Red blood cell protein	F7APQ4	+3	+
Leukocyte elastase inhibitor	Innate immunity	G7P4B6	+27	+
Purine nucleoside phosphorylase (Fragment)	Purine metabolism	G8F5P6	+10	+
Scinderin	Secretory pathway	F6T8Z7	+	+
Serum amyloid A protein	Acute phase protein	F7DY68	+63	+4
Superoxide dismutase [Mn] mitochondrial	Innate immunity	Q8HXP2	+75	+26

¹Label-free quantitative analysis of proteins analyzed by LC-MS/MS. Data labeled with only a “+” symbol denotes proteins that were detected in the infected animals but not in the uninfected control under these experimental conditions.

ISSN: 1559-0275