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Table 4 Univariate and Cox proportional multivariate analyses for recurrence (n = 29) and breast cancer death (n = 17) in the 79 patients validation cohort with ER positive breast cancer, treated with tamoxifen only as systemic adjuvant therapy

From: Proteomics profiling identify CAPS as a potential predictive marker of tamoxifen resistance in estrogen receptor positive breast cancer

VARIABLES

RFS

BCS

HR

95% CI

p-value

HR

95% CI

p-value

Univariate

Lower

Upper

Lower

Upper

Tumor size (T1 vs. T2–3)

1.4

0.67

2.9

0.37

1.3

0.48

3.3

0.63

Node status (pos vs neg)

2.1

0.97

4.6

0.059

5.3

1.51

18.7

0.0092

CAPS (high vs low)

2.4

0.98

6.0

0.049

2.8

0.80

9.6

0.11

Age (<50 vs ≥50 years)

1.00

0.97

1.03

0.82

1.01

0.98

1.05

0.60

ER cont (fmol/μg DNA)

0.87

0.77

0.98

0.026

0.76

0.60

0.95

0.018

PgR cont (fmol/μg DNA)

0.93

0.84

1.03

0.16

0.85

0.71

1.01

0.061

CAPS (high vs low)

2.4

0.98

6.0

0.056

2.8

0.80

9.6

0.11

Multivariate

Tumor size (T1 vs T2–3)

1.4

0.61

3.2

0.43

0.90

0.30

2.7

0.85

Node status (pos vs neg)

1.7

0.72

4.0

0.22

4.7

1.24

18.0

0.024

CAPS (high vs low)

3.6

1.3

9.7

0.011

4.0

1.04

15.1

0.043

Age (<50 vs ≥50 years)

1.00

0.97

1.03

0.87

1.02

0.99

1.06

0.24

ER cont (fmol/μg DNA)

0.88

0.76

1.01

0.073

0.72

0.55

0.96

0.025

PgR cont (fmol/μg DNA)

0.96

0.87

1.07

0.48

0.92

0.77

1,11

0.40

CAPS (high vs low)

3.6

1.3

9.7

0.011

4.0

1.04

15.1

0.043

  1. Abbreviations: RFS Relapse-free survival, BCS breast cancer-specific survival.