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Figure 3 | Clinical Proteomics

Figure 3

From: Direct and rapid mass spectral fingerprinting of maternal urine for the detection of Down syndrome pregnancy

Figure 3

Examination of the variability in m/z profiles from 84 non-aneuploid maternal urine samples as gestation progresses from 12 to 17 weeks of pregnancy. Plot of statistical significance comparisons (p-values) of each mass bin (every 100 m/z from 6000 to 14000 m/z) of normalised data from maternal urinary MALDI – ToF mass spectral profiles. The red lines indicate a statistical significance cut off at p = 0.05. Panel A – kruskall Wallis test comparison of all samples grouped from 12 – 18 weeks gestation, illustrating multiple m/z regions where there is a difference between the profiles as gestation progresses; Panel B – step wise comparisons between 12, 13 and 14 week gestation samples, illustrating that at these gestations there are no differences in the profiles of the non-aneuploid samples; Panel C – step wise comparisons between 15, 16 and 17 week gestation samples, illustrating differences at specific m/z regions but none reach statistical significance at p < 0.05.

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