Table 1 Enriched pathways in OA chondrocytes
From: Comparative proteomic analysis of hypertrophic chondrocytes in osteoarthritis
PathwayName | Gene Names | AdjP-value |
|---|---|---|
General metabolism and cellular processes | ||
Parkin-Ubiquitin Proteasomal System pathway | TUBA1C PSMD4 HSPA1A PSMD2 PSMD6 HSPA2 PSMC1 TUBB | adjP = 1.47e-07 |
Translation Factors | EIF3E EIF4A1 EEF1G EEF1A1 EEF2 EIF3B EEF1D | adjP = 2.60e-07 |
Electron Transport Chain | ATP5B COX6C SLC25A5 UQCRFS1 NDUFB4 ATP5A1 | adjP = 0.0001 |
Cytoplasmic Ribosomal Proteins | RPL8 RPLP0 RPL35A RPL23 RPL10 RPL27 | adjP = 8.18e-05 |
Proteasome Degradation | PSMD4 PSMD2 PSMD6 PSMC1 | adjP = 0.0018 |
TCA Cycle | SUCLA2 IDH3G DLST | adjP = 0.0007 |
Oxidative phosphorylation | ATP5B NDUFB4 ATP5A1 | adjP = 0.0098 |
Adhesion, cytoskeleton remodeling, cell-cell & cell-matrix interactions, endocytosis | ||
Focal Adhesion | ACTG1 RAC1 RAP1B FLNA VASP MAPK1 PDGFRB CAPN1 | adjP = 8.18e-05 |
Regulation of Actin Cytoskeleton | ACTG1 IQGAP1 RAC1 ENAH GSN PFN1 MAPK1 PDGFRB | adjP = 3.12e-05 |
Integrin-mediated cell adhesion | RAC1 RAP1B CAPN2 VASP MAPK1 CAPN1 | adjP = 0.0001 |
Synaptic Vesicle Pathway | AP2A2 AP2A1 CLTC AP2B1 NAPA | adjP = 8.74e-05 |
G13 Signaling Pathway | IQGAP1 RAC1 PFN1 | adjP = 0.0034 |
TOR signaling | RAC1 RRAGC PRKAG1 | adjP = 0.0032 |
Senescence and Autophagy | GSN MMP14 CD44 MAPK1 | adjP = 0.0100 |
Signaling pathways | ||
EGF-EGFR Signaling Pathway | GJA1 IQGAP1 RAC1 HGS AP2A1 AP2B1 MAPK1 | adjP = 0.0003 |
TGF beta Signaling Pathway | RAC1 HGS TRAP1 SPTBN1 SKP1 MAPK1 PRKAR2A | adjP = 0.0001 |
TNF alpha Signaling Pathway | RAC1 PSMD2 TRAP1 BAX SKP1 HSP90AA1 MAPK1 | adjP = 2.36e-05 |
MAPK signaling pathway | RAC1 RAP1B FLNA MAPK1 PDGFRB | adjP = 0.0058 |
Wnt Signaling Pathway | GJA1 RAC1 CTNNB1 | adjP = 0.0063 |
Corticotropin-releasing hormone | GJA1 RAP1B GNB2 GNAS CTNNB1 HSP90AA1 MAPK1 GNAI2 | adjP = 6.10e-06 |
Androgen receptor signaling pathway | RAC1 FHL2 FLNA CTNNB1 CARM1 | adjP = 0.0007 |
TSH signaling pathway | RAP1B GNAS MAPK1 GNAI2 | adjP = 0.0021 |
TWEAK Signaling Pathway | RAC1 CTNNB1 MAPK1 | adjP = 0.0083 |
RANKL-RANK Signaling Pathway | RAC1 FHL2 MAPK1 | adjP = 0.0121 |
Lipid metabolism, eicosanoid metabolism, oxidative stress | ||
metapathway biotransformation | CYP20A1 GSTT1 GSTP1 GSTK1 GPX4 CYP1B1 EPHX1 | adjP = 0.0003 |
cytochrome P450 | CYP20A1 CYB5R1 CYP1B1 CYB5R3 | adjP = 0.0018 |
Fatty Acid Beta Oxidation | CHKB SLC25A20 DECR1 | adjP = 0.0148 |
Prostaglandin Synthesis and Regulation | ANXA6 ANXA1 ANXA2 | adjP = 0.0023 |
Glutathione metabolism | GSTT1 GPX4 | adjP = 0.0150 |