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Table 1 Candidate lung cancer biomarkers identified through MS discovery that were selected for serological characterization

From: Blood-based lung cancer biomarkers identified through proteomic discovery in cancer tissues, cell lines and conditioned medium

Protein

Differentially expressed peptides

Number of samples where differentially expressed peptides observed

Differential expression (Lung cancer/control)

Predicted subcellular localization

Tissues (n = 13)

Cell lines (n = 17)

Conditioned medium (n = 7)

  

CEA (CEACAM5)

CETQNPVSAR

9

1

 

20.4

Cell Membrane

TLTLFNVTRNDTASYK

MDK

YNAQCQETIR

7

4.9

Secreted

EGTCGAQTQR

FENWGACDGGTGTK

VTKPCTPK

YNAQCQETIRVTKPCTPK

MMP2

ESCNLFVLK

 

1

3

21.8

Secreted

TDKELAVQYLNTFYGCPK

ELAVQYLNTFYGCPK

CGNPDVANYNFFPR

YGFCPHEALFTMGGNAEGQPCK

SLPI

SCVSPVKA

3

  

5.5

Secreted

AGVCPPK

SCVSPVK

AGVCPPKK

TFPI

ADDGPCK

 

1

3

10.0

Secreted

QCEEFIYGGCEGNQNR

TTLQQEKPDFCFLEEDPGICR

YFYNNQTK

TIMP1

FVYTPAMESVCGYFHR

11

1

4

34.6

Secreted

HLACLPR

LQSGTHCLWTDQLLQGSEK

LQDGLLHITTCSFVAPWNSLSLAQR

FVGTPEVNQTTLYQRYEIK

AKFVGTPEVNQTTLYQR

FVGTPEVNQTTLYQR

SHNRSEEFLIAGK

EPGLCTWQSLR

  1. Differentially expressed peptides resolved for each marker are listed together with the number of samples (tissues, cell lines or conditioned medium) where peptides with elevated expression in lung cancer were identified. Median ratio represents the overall level of elevated expression combining levels observed for each differentially expressed peptide in disease samples relative to appropriate controls