Examples of the laser microdissections (LMDs) of targeted lesions from a OA and b RA synovial tissues (1, before; 2, after) on the DIRECTOR® slides. The DIRECTOR® slide is similar to a standard glass (uncharged) microscope slide, but has an energy transfer coating on one side of the slide. Tissue sections are mounted on top of the energy transfer coating, and when the slide is turned over, the tissue faces down under the microdissection system. Targeting cells or tissue areas of interest is carried out on computer display. The laser energy is converted to kinetic energy upon striking the coating, vaporizing it and instantly propelling selected tissue features into the collection tube.