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Table 1 Representative 31 proteins with p values <0.0001 in G test, and R SC values >2 or <−2, which means the fold change of a protein higher than 4 or lower than 0.25, in pairwise comparison between RA and OA

From: A proteomic profile of synoviocyte lesions microdissected from formalin-fixed paraffin-embedded synovial tissues of rheumatoid arthritis

Protein entry namea Gene ID Description Length of amino acid Number of samples in which a protein was identified Spectral counts (SpCs) p value in G-test Spectral Index (SpI) R SC
OA (n = 5) RA (n = 15) OA-group RA-group
1A33 HLA-A HLA class I histocompatibility antigen, A-33 alpha chain 365 1 12 2 84 7.667E−08 0.777 2.904
TXND5 TXNDC5 Thioredoxin domain-containing protein 5 432 2 12 4 87 1.929E−06 0.747 2.261
DEF1 DEFA1 Neutrophil defensin 1 94 0 11 0 78 4.879E−10 0.733 4.177
RL7A RPL7A 60S ribosomal protein L7a 266 0 10 0 37 2.032E−05 0.667 3.125
TPM3 TPM3 Tropomyosin alpha-3 chain 284 1 10 5 102 4.128E−07 0.626 2.237
S10A8 S100A8 Protein S100-A8 93 0 9 0 85 8.08E−11 0.600 4.299
VINC VCL Vinculin 1,134 1 9 3 70 1.372E−05 0.567 2.257
S10A9 S100A9 Protein S100-A9 114 0 8 0 109 1.732E−13 0.533 4.654
EZRI EZR Ezrin 586 0 8 0 69 4.951E−09 0.533 4.003
FRIH FTH1 Ferritin heavy chain 183 0 8 0 40 9.239E−06 0.533 3.234
K2C6A KRT6A Keratin, type II cytoskeletal 6A 564 0 7 0 156 1.084E−18 0.467 5.168
PERP1 PACAP Plasma cell-induced resident endoplasmic reticulum protein 189 0 6 0 43 4.21E−06 0.400 3.335
PERM MPO Myeloperoxidase 745 0 5 0 65 1.39E−08 0.333 3.918
1C12 HLA-C HLA class I histocompatibility antigen, Cw-12 alpha chain 366 0 5 0 46 1.922E−06 0.333 3.430
K2C5 KRT5 Keratin, type II cytoskeletal 5 590 0 4 0 93 1.039E−11 0.267 4.427
TRFL LTF Lactotransferrin 710 0 3 0 98 2.886E−12 0.200 4.502
K1C14 KRT14 Keratin, type I cytoskeletal 14 472 0 3 0 81 2.257E−10 0.200 4.231
ACTN1 ACTN1 Alpha-actinin-1 892 0 3 0 47 1.481E−06 0.200 3.460
K2C6C KRT6C Keratin, type II cytoskeletal 6C 564 0 1 0 64 1.799E−08 0.067 3.896
POSTN POSTN Periostin 836 2 5 17 13 5.517E−05 −0.082 −2.170
CBPQ CPQ Plasma glutamate carboxypeptidase 472 1 0 6 0 6.486E−05 −0.200 −4.349
AEBP1 AEBP1 Adipocyte enhancer-binding protein 1 1,158 1 0 6 0 6.486E−05 −0.200 −4.349
COFA1 COL15A1 Collagen alpha-1 (XV) chain 1,388 1 0 7 0 1.354E−05 −0.200 −4.535
MYH11 MYH11 Myosin-11 1,972 1 0 10 0 1.273E−07 −0.200 −4.983
HBG2 HBG2 Hemoglobin subunit gamma-2 147 1 0 25 0 1.278E−17 −0.200 −6.207
ASPN ASPN Asporin 380 2 2 24 12 1.693E−08 −0.222 −2.744
HBD HBD Hemoglobin subunit delta 147 4 5 245 216 9.342E−48 −0.269 −2.012
CO4A C4A Complement C4-A 1,744 2 1 13 4 3.329E−06 −0.290 −3.254
COCA1 COL12A1 Collagen alpha-1 (XII) chain 3,063 2 1 17 5 6.862E−08 −0.294 −3.359
COEA1 COL14A1 Collagen alpha-1 (XIV) chain 1,796 4 6 167 108 4.41E−43 −0.329 −2.449
FMOD FMOD Fibromodulin 376 2 0 8 0 2.845E−06 −0.400 −4.700
  1. aProteins are listed in descending order of SpI-value, and “_HUMAN” are removed from UniProtKG entry names.