Table 1 Representative 31 proteins with p values <0.0001 in G test, and R SC values >2 or <−2, which means the fold change of a protein higher than 4 or lower than 0.25, in pairwise comparison between RA and OA
Protein entry namea | Gene ID | Description | Length of amino acid | Number of samples in which a protein was identified | Spectral counts (SpCs) | p value in G-test | Spectral Index (SpI) | R SC | ||
|---|---|---|---|---|---|---|---|---|---|---|
OA (n = 5) | RA (n = 15) | OA-group | RA-group | |||||||
1A33 | HLA-A | HLA class I histocompatibility antigen, A-33 alpha chain | 365 | 1 | 12 | 2 | 84 | 7.667E−08 | 0.777 | 2.904 |
TXND5 | TXNDC5 | Thioredoxin domain-containing protein 5 | 432 | 2 | 12 | 4 | 87 | 1.929E−06 | 0.747 | 2.261 |
DEF1 | DEFA1 | Neutrophil defensin 1 | 94 | 0 | 11 | 0 | 78 | 4.879E−10 | 0.733 | 4.177 |
RL7A | RPL7A | 60S ribosomal protein L7a | 266 | 0 | 10 | 0 | 37 | 2.032E−05 | 0.667 | 3.125 |
TPM3 | TPM3 | Tropomyosin alpha-3 chain | 284 | 1 | 10 | 5 | 102 | 4.128E−07 | 0.626 | 2.237 |
S10A8 | S100A8 | Protein S100-A8 | 93 | 0 | 9 | 0 | 85 | 8.08E−11 | 0.600 | 4.299 |
VINC | VCL | Vinculin | 1,134 | 1 | 9 | 3 | 70 | 1.372E−05 | 0.567 | 2.257 |
S10A9 | S100A9 | Protein S100-A9 | 114 | 0 | 8 | 0 | 109 | 1.732E−13 | 0.533 | 4.654 |
EZRI | EZR | Ezrin | 586 | 0 | 8 | 0 | 69 | 4.951E−09 | 0.533 | 4.003 |
FRIH | FTH1 | Ferritin heavy chain | 183 | 0 | 8 | 0 | 40 | 9.239E−06 | 0.533 | 3.234 |
K2C6A | KRT6A | Keratin, type II cytoskeletal 6A | 564 | 0 | 7 | 0 | 156 | 1.084E−18 | 0.467 | 5.168 |
PERP1 | PACAP | Plasma cell-induced resident endoplasmic reticulum protein | 189 | 0 | 6 | 0 | 43 | 4.21E−06 | 0.400 | 3.335 |
PERM | MPO | Myeloperoxidase | 745 | 0 | 5 | 0 | 65 | 1.39E−08 | 0.333 | 3.918 |
1C12 | HLA-C | HLA class I histocompatibility antigen, Cw-12 alpha chain | 366 | 0 | 5 | 0 | 46 | 1.922E−06 | 0.333 | 3.430 |
K2C5 | KRT5 | Keratin, type II cytoskeletal 5 | 590 | 0 | 4 | 0 | 93 | 1.039E−11 | 0.267 | 4.427 |
TRFL | LTF | Lactotransferrin | 710 | 0 | 3 | 0 | 98 | 2.886E−12 | 0.200 | 4.502 |
K1C14 | KRT14 | Keratin, type I cytoskeletal 14 | 472 | 0 | 3 | 0 | 81 | 2.257E−10 | 0.200 | 4.231 |
ACTN1 | ACTN1 | Alpha-actinin-1 | 892 | 0 | 3 | 0 | 47 | 1.481E−06 | 0.200 | 3.460 |
K2C6C | KRT6C | Keratin, type II cytoskeletal 6C | 564 | 0 | 1 | 0 | 64 | 1.799E−08 | 0.067 | 3.896 |
POSTN | POSTN | Periostin | 836 | 2 | 5 | 17 | 13 | 5.517E−05 | −0.082 | −2.170 |
CBPQ | CPQ | Plasma glutamate carboxypeptidase | 472 | 1 | 0 | 6 | 0 | 6.486E−05 | −0.200 | −4.349 |
AEBP1 | AEBP1 | Adipocyte enhancer-binding protein 1 | 1,158 | 1 | 0 | 6 | 0 | 6.486E−05 | −0.200 | −4.349 |
COFA1 | COL15A1 | Collagen alpha-1 (XV) chain | 1,388 | 1 | 0 | 7 | 0 | 1.354E−05 | −0.200 | −4.535 |
MYH11 | MYH11 | Myosin-11 | 1,972 | 1 | 0 | 10 | 0 | 1.273E−07 | −0.200 | −4.983 |
HBG2 | HBG2 | Hemoglobin subunit gamma-2 | 147 | 1 | 0 | 25 | 0 | 1.278E−17 | −0.200 | −6.207 |
ASPN | ASPN | Asporin | 380 | 2 | 2 | 24 | 12 | 1.693E−08 | −0.222 | −2.744 |
HBD | HBD | Hemoglobin subunit delta | 147 | 4 | 5 | 245 | 216 | 9.342E−48 | −0.269 | −2.012 |
CO4A | C4A | Complement C4-A | 1,744 | 2 | 1 | 13 | 4 | 3.329E−06 | −0.290 | −3.254 |
COCA1 | COL12A1 | Collagen alpha-1 (XII) chain | 3,063 | 2 | 1 | 17 | 5 | 6.862E−08 | −0.294 | −3.359 |
COEA1 | COL14A1 | Collagen alpha-1 (XIV) chain | 1,796 | 4 | 6 | 167 | 108 | 4.41E−43 | −0.329 | −2.449 |
FMOD | FMOD | Fibromodulin | 376 | 2 | 0 | 8 | 0 | 2.845E−06 | −0.400 | −4.700 |