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Table 4 Specific urinary proteins listed by association and diagnostic accuracy for CKD and rapid kidney function decline

From: Urinary proteomics in chronic kidney disease: diagnosis and risk of progression beyond albuminuria

Protein

Detected peptides

CKD diagnosis

Rapid kidney function decline

P value

OR (StdX)

ROC

Rank

P value

OR (StdX)

ROC

Rank

Collagen alpha-1 (I) chain

33

0.002

0.03

0.941

1

0.004

0.101

0.853

3

CD99 antigen

1

0.004

0.001

0.918

2

0.028

0.008

0.832

5

Uromodulin

3

0.007

0.001

0.98

3

0.019

0.025

0.846

4

Sodium/potassium-transporting ATPase gamma chain

1

0.002

0.032

0.954

4

0.016

0.002

0.93

2

Collagen alpha-1 (II) chain

1

0.002

0.04

0.948

5

0.001

0.063

0.93

1

Collagen alpha-1 (III) chain

15

0.002

0.112

0.882

6

0.013

0.195

0.837

6

Neurosecretory protein VGF

1

0.008

37

0.876

7

0.017

4.58

0.825

7

Osteopontin

2

0.016

0.018

0.863

8

0.99

 

0.5

18

Collagen alpha-2 (I) chain

4

0.012

0.172

0.848

9

0.069

0.35

0.724

13

Transthyretin (Prealbumin)

2

0.086

n.s.

0.892

10

0.062

5.51

0.82

11

Beta-2-microglobulin

1

0.065

n.s.

0.859

11

0.358

1.39

0.811

17

Alpha-2-HS-glycoprotein

2

0.05

n.s.

0.84

12

0.07

2.33

0.86

12

Alpha-1-antitrypsin

3

0.168

n.s.

0.871

13

0.047

11.11

0.811

10

Polymeric-immunoglobulin receptor

1

0.02

0.337

0.77

14

0.097

0.48

0.706

16

Apolipoprotein A-I

1

0.172

n.s.

0.85

15

0.047

9.45

0.822

9

Membrane associated progesterone receptor component 1

1

0.056

0.441

0.801

16

0.103

0.429

0.731

14

Albumin

1

0.397

n.s.

0.845

17

0.17

1.77

0.745

15

Fibrinogen alpha chain

2

0.156

n.s.

0.722

18

0.03

9

0.822

8

  1. Protein names and number of specific peptides detected from this protein are given. Data are given only for the best peptide per protein. Odds ratios are based on unadjusted logistic regression analysis. Peptides with p values <0.10 or with special interest (albumin) were included. Data show p value and odds ratio for outcome associated with one standard deviation change of protein to improve comparability (logistic regression analysis; OR StdX could not be calculated for all associations). Area under the ROC curve is also given. The separate rankings for CKD diagnosis and rapid kidney function decline (>4 ml/min/1.73 m2 per year) represent the mean ranks for p values, standardized OR and ROC.
  2. n.s. not significant.
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Clinical Proteomics

ISSN: 1559-0275