No. | Uniprot ID | Name | Primary gene name | Function/catalytic activity | NSAF ratio | ||
---|---|---|---|---|---|---|---|
Low ROS | Medium ROS | High ROS | |||||
1 | P60709 | Actin, | ACTB | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | 1.48 | 1 | 2.34 |
cytoplasmic 1 | |||||||
2 | P61163 | Alpha-centractin | ACTR1A | Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | 1.82 | 1 | 33.08 |
3 | Q9UHI8 | A disintegrin and metalloproteinase with thrombospondin motifs 1 | ADAMTS1 | Cleaves aggrecan, a proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer | 2.28 | 1.73 | 2.46 |
4 | P49189 | 4-trimethylaminobutyraldehyde dehydrogenase | ALDH9A1 | Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction. Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1′ | 1 | 1 | 11.76 |
5 | P25705 | ATP synthase subunit alpha, mitochondrial | ATP5A1 | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain | 2 | 3.53 | 9.55 |
6 | P06576 | ATP synthase subunit beta, mitochondrial | ATP5B | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain | 2.79 | 2.59 | 9.59 |
7 | P36542 | ATP synthase subunit gamma, mitochondrial | ATP5C1 | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain | 1 | 2.12 | 4.83 |
8 | P27797 | Calreticulin | CALR | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins and cleaves aggrecan at the 1938-Glu-|-Leu-1939 site, within the chondroitin sulfate attachment domain | 0.94 | 0.94 | 3 |
9 | P27824 | Calnexin | CANX | Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the ATPÂ +Â H(2)OÂ =Â ADPÂ +Â phosphate | 1 | 1 | 53.77 |
10 | P78371 | T-complex protein 1 subunit beta | CCT2 | Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role in vitro | 1.41 | 1.58 | 11.35 |
11 | P50991 | T-complex protein 1 subunit delta | CCT4 | Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia | 0.37 | 1.43 | 3.39 |
12 | P48643 | T-complex protein 1 subunit epsilon | CCT5 | Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides | 0.57 | 1.39 | 10.45 |
13 | P40227 | T-complex protein 1 subunit zeta | CCT6A | Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro in the folding of actin and tubulin | 1 | 1 | 46.53 |
14 | Q99832 | T-complex protein 1 subunit eta | CCT7 | Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role in vitro in the folding of actin and tubulin | 2.26 | 2.48 | 8.1 |
15 | Q13618 | Cullin-3 | CUL3 | Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme, involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division | 1 | 11.18 | 77.7 |
16 | P07954 | Fumaratehydratase, mitochondrial | FH | Also acts as a tumor suppressor | 21.75 | 29.87 | 153.16 |
NADH + acceptor = NAD(+) + reduced acceptor | |||||||
17 | O14556 | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific | GAPDHS | May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility | 1 | 1.44 | 10.4 |
ATPÂ +Â H(2)OÂ =Â ADPÂ +Â phosphate | |||||||
18 | P07900 | Heat shock protein HSP 90-alpha | HSP90AA1 | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity | 1.58 | 1 | 2.24 |
19 | P14625 | Endoplasmin | HSP90B1 | Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD) | 1 | 1.54 | 3.02 |
20 | P54652 | Heat shock-related 70Â kDa protein 2 | HSPA2 | In co-operation with other chaperones, Hsp70 stabilize pre-existent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles | 1.43 | 1 | 1.93 |
21 | P11021 | 78Â kDa glucose-regulated protein | HSPA5 | Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate | 0.94 | 1 | 3.3 |
22 | P10809 | 60Â kDa heat shock protein, mitochondrial | HSPD1 | Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress condition | 1.81 | 1 | 7.75 |
23 | P52292 | Importin subunit alpha-1 | KPNA2 | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite nuclear localization signal motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus | 1 | 1 | 12.34 |
24 | P00338 | L-lactate dehydrogenase A chain | LDHA | (S)-lactate + NAD(+) = pyruvate + NADH | 2.02 | 2.16 | 2.28 |
25 | P40926 | Malate dehydrogenase, mitochondrial | MDH2 | (S)-malate + NAD+ = oxaloacetate + NAD | 1.09 | 7.08 | 8.62 |
26 | P08473 | Neprilysin | MME | Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3Â kDa containing neutral bulky aliphatic or aromatic amino acid residues | 2.61 | 2.8 | 2.24 |
27 | P28331 | NADH-ubiquinone oxidoreductase 75Â kDa subunit, mitochondrial | NDUFS1 | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain | 2.44 | 1 | 4.11 |
28 | P55786 | Puromycin-sensitive aminopeptidase | NPEPPS | Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecule 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH | 1.53 | 0.67 | 3.19 |
29 | Q9Y265 | RuvB-like 1 | RUVBL1 | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5′ to 3′) activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2AZ/H2AFZ from the nucleosome | 0.3 | 0.67 | 2.98 |
30 | Q9Y230 | RuvB-like 2 | RUVBL2 | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5′ to 3′) activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome | 1 | 0.75 | 13.69 |
31 | P17987 | T-complex protein 1 subunit alpha | TCP1 | Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role in folding of actin and tubulin | 1.65 | 1.6 | 3.96 |
32 | P68371 | Tubulin beta-4B chain | TUBB4B | Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain | 1.02 | 1.85 | 6.12 |
33 | P31930 | Cytochrome b-c1 complex subunit 1, mitochondrial | UQCRC1 | This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 | 1 | 1 | 21.68 |
34 | P55072 | Transitional endoplasmic reticulum ATPase | VCP | Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus | 1.06 | 1.65 | 4.15 |
35 | P63104 | 14-3-3 protein zeta/delta | YWHAZ | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the(S)-malate = fumarate + H2O | 1.22 | 0.99 | 2.12 |