Fig. 5
From: Proteomic profiling identifies specific histone species associated with leukemic and cancer cells
Histone H3 isoforms altered in leukemic and cancer cells. a A representative histone H3 peak 1 LC/MS spectrum. The peaks that are significantly changed in CLL, bladder and breast cancer cells are highlighted with arrows (CLL-green, bladder-red and breast-blue). b, c Representative spectrum and histogram, respectively, showing the relative decrease in abundance of the peak with molecular weight ~15,510 Da in CLL B cells. The relative abundance of each isoform has been determined as described in Fig. 2b. d, e Representative spectrum and histogram, respectively, showing the relative abundance of the peak with molecular weight ~15,296 Da in bladder cancer. f A spectrum representing the decreased abundance of the peak with molecular weight ~15,476 Da in breast cancer cells. g A representative histone H3 peak 2 LC/MS spectrum. The peaks are labeled as described above