Skip to main content
Fig. 1 | Clinical Proteomics

Fig. 1

From: Histone post-translational modifications in frontal cortex from human donors with Alzheimer’s disease

Fig. 1

Variability in replicate measurements. a The ratio of modified H3 peptide KacQLATKacAAR to H3 was measured in six replicate injections of a frontal cortex sample from a normal donor and individual ratios were normalized to their average (n = 6) and plotted to show the negligible variability between replicate injections. b The ratio of non-modified H2B to H3 plotted for biological replicates from normal donors (n = 6) and normalized to the average, showing negligible variability between biological replicates for the stoichiometric H2B/H3 ratio. c The ratio of KacQLATKacAAR to H3 plotted for the average of two injections for each biological sample from normal donors (n = 6) and normalized to the average for all measurements (n = 12), showing variability in PTM is attributed to differences in donors and not due to inherent variability in MRM

Back to article page

Clinical Proteomics

ISSN: 1559-0275