Fig. 2

Histone PTMs in frontal cortex. a Measured peak areas of each quantified peptide were normalized to the peak area of different histone subunits. The relative standard deviation (n = 12) for each quantified peptide in normal and AD frontal cortex is shown grouped by the histone in which the peptides are located. The identity of the PTM measurements is presented in the graph in b, which appears in the same order. b Changes in histone PTMs in AD-affected human frontal cortex. Measurements were performed using human frontal cortex from normal (n = 6) and AD-affected (n = 6) donors (Additional file 1: Table S1) and two experimental replicates per donor (n = 12 total measurements per condition). Q-peptide transitions are summarized in Table 1. Data presented as mean ± SD. PTMs are (ac) acetylation, (me) methylation, and (ub) ubquitination. *p < 0.05; **p < 0.01; ***p < 0.001