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Fig. 7 | Clinical Proteomics

Fig. 7

From: Label-free mass spectrometric analysis reveals complex changes in the brain proteome from the mdx-4cv mouse model of Duchenne muscular dystrophy

Fig. 7

Comparative immunoblot analysis of normal versus mdx-4cv brain. Shown are representative immunoblots (a–d) of key proteomic hits identified by mass spectrometric analysis. Lanes 1 and 2 represent total extracts from control wild type (wt) and mdx-4cv brain, respectively. Blots were labelled with antibodies to the AnxA5 isoform of annexin (a), the intermediate filament protein vimentin (VIM) (b), the nuclear envelope protein lamin B1 (LAM-B1) (c) and the plasma membrane Ca2+-ATPase isoform PMCA2 (d). Arrowheads mark the main immuno-labelled protein bands in individual panels. Graphical representations of the immuno-decoration levels are shown in panels e–h: Student’s t-test, unpaired; n = 4; *p < 0.05; **p < 0.01; ***p < 0.001

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