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Table 1 Key technological developments for novel MS-based biomarker discovery

From: Advances in mass spectrometry-based clinical biomarker discovery

  Protein PTM Flux Small molecule metabolite
Detection Schema Shotgun, top-down proteomics Shotgun, top-down proteomics Kinetic flux profiling Imaging-MS, LC–MS
Key Technology Developments Dynamic range, throughput, quantification strategies Analytical sensitivity, throughput, stability Algorithms for relating labeling patterns and flux, complete understanding of pathways for constraining calculation of flux Analytical sensitivity, structure deconvolution, isobaric separation
Possible Clinical Applications Cancer and cardiovascular screening and prognosis Cancer and cardiovascular screening and prognosis Pharmacometabolomics Basis for new scanning technologies, gut microbiome implications, screening of oncometabolites