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Table 1 Key technological developments for novel MS-based biomarker discovery

From: Advances in mass spectrometry-based clinical biomarker discovery

 

Protein

PTM

Flux

Small molecule metabolite

Detection Schema

Shotgun, top-down proteomics

Shotgun, top-down proteomics

Kinetic flux profiling

Imaging-MS, LC–MS

Key Technology Developments

Dynamic range, throughput, quantification strategies

Analytical sensitivity, throughput, stability

Algorithms for relating labeling patterns and flux, complete understanding of pathways for constraining calculation of flux

Analytical sensitivity, structure deconvolution, isobaric separation

Possible Clinical Applications

Cancer and cardiovascular screening and prognosis

Cancer and cardiovascular screening and prognosis

Pharmacometabolomics

Basis for new scanning technologies, gut microbiome implications, screening of oncometabolites