From: Advances in mass spectrometry-based clinical biomarker discovery
 | Protein | PTM | Flux | Small molecule metabolite |
---|---|---|---|---|
Detection Schema | Shotgun, top-down proteomics | Shotgun, top-down proteomics | Kinetic flux profiling | Imaging-MS, LC–MS |
Key Technology Developments | Dynamic range, throughput, quantification strategies | Analytical sensitivity, throughput, stability | Algorithms for relating labeling patterns and flux, complete understanding of pathways for constraining calculation of flux | Analytical sensitivity, structure deconvolution, isobaric separation |
Possible Clinical Applications | Cancer and cardiovascular screening and prognosis | Cancer and cardiovascular screening and prognosis | Pharmacometabolomics | Basis for new scanning technologies, gut microbiome implications, screening of oncometabolites |