Phosphotyrosine profiling of curcumin-induced signaling

Table 2 A partial list of novel kinases/phosphatases regulated by curcumin

Gene symbol	Protein	Site	Phosphopeptide sequence	Fold change (curcumin/DMSO)
PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Y536	GQESEyGNITYPPAMK	5.1
ABL2	Abelson tyrosine-protein kinase 2	Y647	yELTGLPEQDR	4.4
INPPL1	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	Y986	NSFNNPAyYVLEGVPHQLLPPEPPSPAR	2.8
MAPK11	Mitogen-activated protein kinase 11	Y182	QADEEMTGyVATR	2.2
PTPRK	Receptor-type tyrosine-protein phosphatase kappa	Y858	CEGTESPyQTGQLHPAIR	2.5
FRK	Fyn-related Src family tyrosine kinase	Y497	LEDYFETDSSySDANNFIR	0.5
PEAK1	Pseudopodium enriched atypical kinase 1	Y635	IVINPNAyDNLAIYK	0.5
TNK2	Activated CDC42 kinase 1	Y827	yATPQVIQAPGPR	0.5
AXL	Tyrosine-protein kinase receptor UFO	Y598	yVLCPSTTPSPAQPADR	0.5
PTPRE	Receptor-type tyrosine-protein phosphatase epsilon	Y638	VVQDFIDIFSDyANFK	0.5

ISSN: 1559-0275