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Fig. 2 | Clinical Proteomics

Fig. 2

From: N-glycosylation proteome enrichment analysis in kidney reveals differences between diabetic mouse models

Fig. 2

Multivariate analyses. a A PCA and b an OPLS-DA of the STZ mouse model where all 505 identified proteins were included. The healthy NoSTZ and diabetic STZ mouse groups were not well separated in the unsupervised PCA, but were well separated in the supervised OPLS-DA. c A PCA and d an OPLS-DA of the db/db mouse model including all 395 identified proteins. The healthy db/+ group was clearly separated from the db/db vehicle and db/db insulin groups in both multivariate models. In the PCA, the two db/db groups were not well separated, but they were clearly separated in the OPLS-DA. Statistics of the multivariate models are shown in an Additional file 2: Panel A. e A heat map with hierarchical clustering of the NoSTZ and STZ mouse groups including 87 proteins with P < 0.05 cutoff. Panel F shows a heat map with hierarchical clustering of the db/+ and db/db mouse groups including 227 proteins with P < 0.05 cutoff. The clustering was done using Qlucore v. 3.2

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