Fig. 3

Differences and similarities between the db/db and STZ mouse model. Panel A shows proteins with higher protein abundance in the STZ and db/db vehicle mouse groups compared to the healthy NoSTZ and db/+ control groups in the two mouse models. Panel B shows proteins with lower abundances in the STZ and db/db vehicle mouse groups compared to their healthy littermates. Panel C shows proteins with differently affected protein abundances in the two mouse models. Panel D shows proteins with significantly regulated protein abundance in the db/db mouse model and a trend to significant regulation in the STZ mouse model and thereby a trend towards differently affected protein regulation in the two mouse models. Two-tailed Students t test was used for calculation of significance level when 2 groups were included and one-way ANOVA with Tukey post hoc test was used for the calculations including the db/db insulin group in the db/db mouse model. Graphs are shown with mean and 95 % CI and P < 0.05 is considered significant