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Table 1 Mouse parameters in the db/db and STZ mouse models

From: N-glycosylation proteome enrichment analysis in kidney reveals differences between diabetic mouse models

  db/db mouse model STZ mouse model
Control db/+ (n = 5) db/db (n = 5) Insulin db/db (n = 5) P valueA Control (STZ) (n = 6) STZ (n = 6) P valueB
  10 weeks old, baseline (insulin dosing start) 10 weeks old, baseline, 2 weeks after STZ
BG (mM) 8.85 ± 0.48 19.27 ± 2.29 24.34 ± 1.28 <0.002§ <0.001$ 6.50 ± 0.27 22.1 ± 1.60 <0.001
HbA1c (%) 4.06 ± 0.08 6.44 ± 0.48 7.88 ± 0.44 <0.003§ <0.001$ <0.05 NA
AER (μg/24 h) 42.5 ± 9.8, n = 4 420.8 ± 111.9 529.3 ± 115 <0.017§ <0.06$ 40.8 ± 16.2, n = 5 408 ± 114 <0.033
BW (g) 27.1 ± 0.9 46.66 ± 0.5 47.92 ± 0.2 <0.001§,$ 25.2 ± 1.1 23.6 ± 0.4 ns
  16 weeks old, 6 weeks after insulin dosing start 14 weeks old, 6 weeks after STZ
BG (mM) 8.4 ± 0.33 22.88 ± 1.86 16.14 ± 1.61 <0.001§ <0.007$ <0.017 5.63 ± 0.25 30.9 ± 3.19 <0.001
HbA1c (%) 4.16 ± 0.10 7.94 ± 0.62 7.32 ± 0.23 <0.001§,$ 3.62 ± 0.031 6.95 ± 0.1 <0.001
AER (μg/24 h) 59.4 ± 13.3, n = 4 855.3 ± 272 488.6 ± 61.2 <0.024§ 55.6 ± 5.39, n = 5 424 ± 71 <0.012
BW (g) 31 ± 0.8 54 ± 3.2 57.2 ± 1.1 <0.001§,$ 28.1 ± 1.0 24.8 ± 0.5 <0.018
  22 weeks old, 12 weeks after insulin dosing start 18 weeks old, 10 weeks after STZ
BG (mM) 8.91 ± 0.28 23.12 ± 2.54 21.23 ± 1.49 <0.001§,$ 8.57 ± 1.21 33.4 ± 1.45 <0.001
HbA1c (%) 4.3 ± 0.07 8.52 ± 0.70 6.78 ± 0.23 <0.001§ <0.005$ <0.035 3.75 ± 0.06 7.60 ± 0.13 <0.001
AER (μg/24 h) 112.2 ± 54.5, n = 4 930.2 ± 184.8 795.1 ± 183.8 <0.015§ <0.039$ 55.7 ± 12.0, n = 5 578 ± 117 <0.004
BW (g) 32.7 ± 0.7 53.7 ± 3.8 62.3 ± 0.9 <0.001§,$ <0.05 30 ± 0.5 25.3 ± 1.2 <0.007
  1. The obtained mouse parameters in the db/db and STZ mouse models show that the db/db vehicle, db/db insulin and STZ mice are diabetic and display a similar degree of diabetes and DN. The data shown at baseline correspond to dosing start of vehicle or insulin in both models (2 weeks after STZ intervention). For comparisons within the db/db mouse model one-way ANOVA with Tukey post hoc test was usedA. The P values for the pairwise comparison within the db/db mouse model is shown as § (db/+ vs. db/db vehicle), $ (db/+ vs. db/db insulin) and € (db/db vehicle vs. db/db insulin). For the STZ mouse model two-tailed Student’s t test for equal variance was usedB for P value calculations. Data are presented as mean ± SEM, P < 0.05 is considered significant