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Table 1 Mouse parameters in the db/db and STZ mouse models

From: N-glycosylation proteome enrichment analysis in kidney reveals differences between diabetic mouse models

 

db/db mouse model

STZ mouse model

Control db/+ (n = 5)

db/db (n = 5)

Insulin db/db (n = 5)

P valueA

Control (STZ) (n = 6)

STZ (n = 6)

P valueB

 

10 weeks old, baseline (insulin dosing start)

10 weeks old, baseline, 2 weeks after STZ

BG (mM)

8.85 ± 0.48

19.27 ± 2.29

24.34 ± 1.28

<0.002§

<0.001$

6.50 ± 0.27

22.1 ± 1.60

<0.001

HbA1c (%)

4.06 ± 0.08

6.44 ± 0.48

7.88 ± 0.44

<0.003§

<0.001$

<0.05€

–

–

NA

AER (μg/24 h)

42.5 ± 9.8, n = 4

420.8 ± 111.9

529.3 ± 115

<0.017§

<0.06$

40.8 ± 16.2, n = 5

408 ± 114

<0.033

BW (g)

27.1 ± 0.9

46.66 ± 0.5

47.92 ± 0.2

<0.001§,$

25.2 ± 1.1

23.6 ± 0.4

ns

 

16 weeks old, 6 weeks after insulin dosing start

14 weeks old, 6 weeks after STZ

BG (mM)

8.4 ± 0.33

22.88 ± 1.86

16.14 ± 1.61

<0.001§

<0.007$

<0.017€

5.63 ± 0.25

30.9 ± 3.19

<0.001

HbA1c (%)

4.16 ± 0.10

7.94 ± 0.62

7.32 ± 0.23

<0.001§,$

3.62 ± 0.031

6.95 ± 0.1

<0.001

AER (μg/24 h)

59.4 ± 13.3, n = 4

855.3 ± 272

488.6 ± 61.2

<0.024§

55.6 ± 5.39, n = 5

424 ± 71

<0.012

BW (g)

31 ± 0.8

54 ± 3.2

57.2 ± 1.1

<0.001§,$

28.1 ± 1.0

24.8 ± 0.5

<0.018

 

22 weeks old, 12 weeks after insulin dosing start

18 weeks old, 10 weeks after STZ

BG (mM)

8.91 ± 0.28

23.12 ± 2.54

21.23 ± 1.49

<0.001§,$

8.57 ± 1.21

33.4 ± 1.45

<0.001

HbA1c (%)

4.3 ± 0.07

8.52 ± 0.70

6.78 ± 0.23

<0.001§

<0.005$

<0.035€

3.75 ± 0.06

7.60 ± 0.13

<0.001

AER (μg/24 h)

112.2 ± 54.5, n = 4

930.2 ± 184.8

795.1 ± 183.8

<0.015§

<0.039$

55.7 ± 12.0, n = 5

578 ± 117

<0.004

BW (g)

32.7 ± 0.7

53.7 ± 3.8

62.3 ± 0.9

<0.001§,$

<0.05€

30 ± 0.5

25.3 ± 1.2

<0.007

  1. The obtained mouse parameters in the db/db and STZ mouse models show that the db/db vehicle, db/db insulin and STZ mice are diabetic and display a similar degree of diabetes and DN. The data shown at baseline correspond to dosing start of vehicle or insulin in both models (2 weeks after STZ intervention). For comparisons within the db/db mouse model one-way ANOVA with Tukey post hoc test was usedA. The P values for the pairwise comparison within the db/db mouse model is shown as § (db/+ vs. db/db vehicle), $ (db/+ vs. db/db insulin) and € (db/db vehicle vs. db/db insulin). For the STZ mouse model two-tailed Student’s t test for equal variance was usedB for P value calculations. Data are presented as mean ± SEM, P < 0.05 is considered significant