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Table 2 Selected proteins identified in both mouse models with opposite or similar protein regulation

From: N-glycosylation proteome enrichment analysis in kidney reveals differences between diabetic mouse models

Uniprot ID Description Short name STZ versus NoSTZ db/db versus db/+ db/db insulin versus dbdbB Kidney CompartmentC
Protein abuncance level P value Protein abundance level P value
P09055 Integrin beta-1 ITGB1 Up <0.012 Down <0.002 G = H, T = L
Q8C3K6 Sodium/glucose cotransporter 1 SGLT1 Down <0.018 Up <0.008 T = M
O54990A Prominin-1 PROM1 Down <0.049 Up <0.001 T = H
Q3TQ02 Alkaline phosphatase, unreviewed ALPL Down <0.037 Up <0.001 T = M
Q3TA96 Lysosomal membrane glycoprotein 1, unreviewed LAMP1 Up <0.011 Up <0.018 G = H, T = H
Q07797 Galectin-3-binding protein GAL-3BP Up <0.001 Up <0.001 G = L, T = L
Q62470-2 Integrin alpha-3, isoform 2 ITGA3 Up <0.03 Up <0.001 G = M, T = H
Q8QZW3 Family with sequence similarity 151, member A F151A Down <0.001 Down UpB <0.011 <0.01B T = H
A0PJK7 Cadherin-related family member 5, unreviewed CDHR5 Down <0.016 Down Tr upB <0.006 <0.099B T = H
Q61847-2 Meprin A subunit beta, isoform 2 MEP1B Down <0.008 Down <0.002 ND, RNA ND
Q6IR20 Solute carrier organic anion transporter family, member 1a6, unreviewed SLC1A6 Down <0.030 Down UpB <0.001 <0.032B G = L, T = L
  1. 11 of the 27 VIP proteins had significantly different abundances in both the STZ and the db/db mouse models. Uniprot accession number, name of the protein and a short name is shown for all included proteins together with the direction of change in protein abundance level in the diabetic mice compared to the healthy mice within each mouse model and the P value. AIn PROM1, there was significant difference in intragroup variance. Two-tailed Student’s t test for equal variance was used for P value calculations except for the cases where insulin had an effect on the protein level, indicated byB. One-way ANOVA with Tukey post hoc test for correction of multiple comparisons was used for db/db insulin and db/db vehicle comparisons. P < 0.05 was considered significant. CKidney compartments were obtained from The Human Protein Atlas [28] using antibody staining where G glomerulus, T tubulus, ND no detected protein, L low, M medium, H high protein expression, RNR means that RNR was detected in the indicated compartment but no protein expression has been confirmed. Tr trend, with P < 0.1, > 0.05