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Table 3 Proteins in the top rated networks in IPA in both mouse models conform

From: N-glycosylation proteome enrichment analysis in kidney reveals differences between diabetic mouse models

  Molecules in network Score Focus mol. Top diseases and functions
db/db     
1 AQP2, ATP1B1, CTSV, DPEP1, EMILIN1, FAM151A, HSPA8, ILK, ITGA3, KLK3, MEP1A, MEP1B, PITX2, PKD1, SLC5A10, STUB1, SYNE1, TREH 11 13 Cell-to-cell signaling and interaction, renal and urological system development and function, organ morphology
2 AQP11, BICC1, CA3, CLCN5, CLU, CUBN, EGF, EGFR, ITGA1, ITGB1, LGMN, LRP2, SLC34A2, SOD1 6 8 Organ morphology, organismal development, renal and urological system development and function
3 ACE2, COL4A3, CTGF, FN1, LAMA1, LAMA5, LAMB1, LAMB2, LAMC1 5 6 Tissue development, decreased levels of albumin, tissue morphology
4 ADIPOQ, ATP2B1, BGN, CALB1, COL18A1, COL1A1, COL1A2, COL4A1, COL4A3, CTGF, CYP27B1, DCN, FAS, FBN1, FCGR2B, ICAM1, IFNG, ITGAV, KL, LEP, LUM, PARP1, SLC34A1, SLC9A3, SLC9A3R1, SMAD4, SMAD7, SPARC, TGFB1, TNF, TNFRSF1B, TRPV5, UMOD, VCAM1, VDR 5 11 Cellular movement, hematological system development and function, immune cell trafficking
STZ     
1 AK2, ALDOB, AQP1, ATP1B1, AVPR2, DPEP1, EMILIN1, FAM151A, KLK3, MEP1A, MEP1B, MIOX, NAPSA, PITX2, PKD1, SLC5A10, TREH, TTR 10 13 Small molecule biochemistry, hematological system development and function, tissue development
2 ACE2, ACTA2, AQP11, BICC1, CLU, COL1A1, COL1A2, COL4A1, COL4A3, CTGF, Ccl2, EGF, EGFR, FCGR2B, FN1, ICAM1, ITGA1, ITGAV, ITGB1, LAMA1, LAMA5, LAMB1, LAMB2, LAMC1, PARP1, PKD1, RALBP1, SMAD3, SMAD4, SMAD7, TGFB1, TNF, TNFRSF1B, UMOD, VEGFA 8 16 Organismal injury and abnormalities, cellular movement, hematological system development and function
3 BGN, COL6A3, DCN, FAS, FBN1, LUM 4 5 Hair and skin-, skeletal and muscular system-development and function, organ morphology
4 CA2, CALB1, CYP27B1, EZR, KL, MSN, S100G, SLC34A1, SLC9A3R1, TRIM24, TRPV5, VDR 3 6 Drug metabolism, lipid metabolism, molecular transport
  1. The top rated IPA networks are shown with the included proteins together with the IPA score, the number of molecules included from the dataset and the major diseases and functions of the networks. Several of the same proteins were included in network 1 from both mouse models and although all networks are slightly overlapping, there is major overlap between networks 2–4 in both mouse models. Although the same proteins were included in the networks in both mouse models, they were not always regulated similarly