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Table 4 Insulin effect on protein abundance in the db/db mouse model

From: N-glycosylation proteome enrichment analysis in kidney reveals differences between diabetic mouse models

Uniprot ID Description Short name db/db versus db/+ db/db insulin versus db/db Kidney compartmentB
Protein abundance level P value Protein abundance level P value
Away from healthy control
P19137/F8VQ40A Laminin subunit alpha 1 LAMA1 Down <0.039 Down <0.006 G = M, T = H
G5E8Q8 Adhesion G protein-coupled receptor 116 GPR116 Down <0.019 Down <0.027 ND, RNA T = H, G = L
E9Q3Q6 CD166 antigen, activated leukocyte cell adhesion molecule, unreviewed ALCAM Up <0.018 Up <0.033 T
Insulin increases protein abundance towards healthy control
Q3TDY6 Tripeptidyl peptidase I, PUP TPP1 Down <0.005 Up <0.005 G = L, T = H
A2ARV4 Low-density lipoprotein receptor-related protein 2 LRP2 Down <0.001 Up <0.023 T
Q8VBZ3 Cleft lip and palate associated transmembrane protein 1 CLPT1 Down <0.001 Up <0.01 ND, RNA T = H, G = L
Insulin reduces protein abundance towards healthy control
Q9JKR6 Hypoxia up-regulated protein 1 HYOU1 Up <0.081 Down <0.029 ND, RNA T
Q1MXF9 Sodium channel beta4 subunit, unreviewed SCN4B Up <0.001 Down <0.001 G = L, T = M
Q3U4F3 Acid phosphatase 2, lysosomal, PUP ACP2 Up <0.019 Down <0.004 ND, RNA T
A2AKI5 Integrin alpha-V light chain, unreviewed ITGAV Up <0.001 Down <0.016 G = H, T = M
Q3UP74 Alanyl (membrane) aminopeptidase, PUP ANPEP Up <0.001 Down <0.047 T
Q9JHJ8 Inducible T-cell co-stimulator ligand ICOSL Up <0.001 Down <0.007 G = L, T = M
  1. In addition to the effect insulin had on some of the 27 VIP proteins, the abundances of 12 of the 153 proteins identified in both mouse models were affected by insulin. The protein abundance level shown as up or down and the P values are valid for the first group compared to the second group (db/db compared to the db/+ and db/db insulin compared to db/db respectively). Protein data is reported as in Table 2, but the STZ mouse data is not shown, as there were no significant differences except for in LAMA1. ALAMA1 was identified in the STZ mouse model solely with Uniprot accession P19137 and in the db/db mouse model solely with Uniprot accession F8VQ40 (unreviewed). The sequences share 99.7 % identity and differ in length by 1 amino acid (aa) (3084 and 3083 aa respectively). The abundances of P19137 and F8VQ40 were assumed comparable. BThe kidney compartment reported in the last column corresponds to the findings reported in the Human Protein Atlas [28]. One-way ANOVA with Tukey post hoc test for multiple comparison correction was used for P value calculations, P < 0.05 was considered significant. PUP putative uncharacterized protein