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Fig. 4 | Clinical Proteomics

Fig. 4

From: OLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages

Fig. 4

Immunohistochemical staining results obtained for KNG1. a Representative staining pictures for KNG1 in diverticular disease tissues (DI and DH), adenoma low grade (ADN LG)/high grade (ADN HG) and adenocarcinoma (ADK) tissues (scale bar 100 µm). b Quantification summary for KNG1. The relative percentage calculated over all the categories of signal (from “none” to “gradation”) are detailed in the table. The highest value obtained is underlined in colour in each patient group represented by histograms and significant differences were obtained between DH versus pT2 (p < 0.001), DH versus pT3 (p < 0.05), DH versus pT4 (p < 0.01), ADN low grade versus pT2 (p < 0.001), ADN low grade versus pT3 (p < 0.05), ADN low grade versus pT4 (p < 0.01), ADN high grade versus pT2 (p < 0.05), pT1 versus pT2 (p < 0.05) DI versus ADN low grade (p < 0.05). DH diverticulitis (adjacent normal tissue), DI diverticulitis inflammatory (diverticulitis zone itself), ADK adenocarcinome, ADN LG adenoma low grade, ADN HG adenoma high grade

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