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Fig. 5 | Clinical Proteomics

Fig. 5

From: A clinical perspective on the utility of alpha 1 antichymotrypsin for the early diagnosis of calcific aortic stenosis

Fig. 5

SRM validation of the differences in AACT found using LC-MS/MS. a Chromatograms of secretome samples showing the transitions of the 2 proteotypic peptides: ITLLSALVETR (A.1) and LYGSEAFATDFQDSAAAK (A.2). As it is shown in the figure, the m/z values selected in the first quadrupole were 608.37 and 946.44, respectively. On the right, quantification of the three transitions (area under the curve) that were monitored for each peptide. The different m/z values selected in the third quadrupole are indicated in the figure. b Chromatograms of plasma samples showing the transitions of the proteotypic peptide AVLDVFEEGTEASAATAVK (m/z 954.48) and quantification of each transition (area under the curve) in plasma samples. The different m/z values selected in the third quadrupole are indicated in the figure

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Clinical Proteomics

ISSN: 1559-0275