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Table 2 List of proteins with different abundance in AICH patients (\(\overline{\text{x}} \,{ + }\,{\text{sd}}\))

From: Identification of novel biomarker and therapeutic target candidates for acute intracerebral hemorrhage by quantitative plasma proteomics

No. UniProt accession Symbol Entrez gene name Abundance in AICH Abundance in NC Fold change 95% CI for fold change P value
1 A0A024R035 C9 Complement component 9 1.087 ± 0.109 0.785 ± 0.204 1.256 ± 0.258 1.256 (1.092, 1.420) 0.016
2 A0A024R4F1 ENO1 Enolase 1, (ɑ) 1.386 ± 0.582 0.952 ± 0.521 1.304 ± 0.608 1.304 (0.918, 1.690) 0.038
3 A0A087X271 CNN2 Calponin 2 1.023 ± 0.165 1.404 ± 0.134 −1.268 ± 0.278 −1.268 (−1.560, −0.977) 0.008
4 A0A0C4DFQ9 DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 0.571 ± 0.394 2.086 ± 0.497 −4.096 ± 4.251 −4.096 (−8.557, 0.367) 0.013
5 A2VCK8 TMSB10/TMSB4X Thymosin beta 10 1.418 ± 0.601 0.634 ± 0.262 1.824 ± 0.994 1.824 (1.193, 2.456) 0.049
6 B4E1N5 APOL1 Apolipoprotein L, 1 1.197 ± 0.287 0.895 ± 0.266 1.225 ± 0.342 1.225 (1.007, 1.442) 0.028
7 D6RB59 EXOC3 Exocyst complex component 3 1.280 ± 0.023 0.433 ± – 2.304 ± 1.130 2.304 (−0.502, 5.109) 0.022
8 E9PN51 NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23 kDa (NADH-coenzyme Q reductase) 0.906 ± 0.009 0.364 ± – 1.995 ± 0.862 1.995 (−0.146, 4.135) 0.013
9 F2RM37 F9 Coagulation factor IX 1.005 ± 0.100 0.750 ± 0.236 1.227 ± 0.258 1.227 (1.064, 1.391) 0.038
10 F8VV32 LYZ Lysozyme 1.031 ± 0.265 1.425 ± 0.364 −1.321 ± 0.365 −1.321 (−1.553, −1.089) 0.017
11 G3V2H1 MPP5 Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 0.586 ± 0.174 1.937 ± 0.301 −2.699 ± 1.559 −2.699 (−4.335, −1.063) 0.007
12 H7C267 PES1 Pescadillo ribosomal biogenesis factor 1 0.497 ± 0.023 2.735 ± – −4.005 ± 2.608 −4.005 (−10.484, 2.475) 0.008
13 H7C4S2 HBP1 HMG-box transcription factor 1 0.999 ± 0.020 0.398 ± – 2.006 ± 0.872 2.006 (−0.159, 4.171) 0.025
14 L8EB32 COL14A1 Collagen, type XIV, ɑ 1 1.054 ± 0.411 2.574 ± 0.454 −2.162 ± 1.206 −2.162 (−3.428, −0.896) 0.005
15 P00739 HPR Haptoglobin-related protein 1.106 ± 0.505 0.440 ± 0.096 2.007 ± 1.185 2.007 (1.254, 2.760) 0.046
16 P02671 FGA Fibrinogen ɑ chain 1.050 ± 0.230 0.694 ± 0.114 1.342 ± 0.375 1.342 (1.103, 1.580) 0.026
17 P06396 GSN Gelsolin 0.947 ± 0.096 1.367 ± 0.326 −1.321 ± 0.274 −1.321 (-1.494, −1.147) 0.003
18 P06727 APOA4 Apolipoprotein A-IV 0.796 ± 0.115 1.418 ± 0.334 −1.562 ± 0.467 −1.562 (−1.859, −1.266) <0.001
19 P18065 IGFBP2 Insulin-like growth factor binding protein 2, 36 kDa 1.230 ± 0.238 1.742 ± 0.612 −1.327 ± 0.343 −1.327 (−1.687, −0.966) 0.041
20 P18428 LBP Lipopolysaccharide binding protein 1.180 ± 0.309 0.700 ± 0.167 1.457 ± 0.504 1.457 (1.137, 1.778) 0.005
21 P19652 ORM2 Orosomucoid 2 0.858 ± 0.176 0.625 ± 0.110 1.248 ± 0.304 1.248 (1.055, 1.442) 0.036
22 Q08830 FGL1 Fibrinogen-like 1 0.992 ± 0.162 0.543 ± 0.087 1.552 ± 0.491 1.552 (1.036, 2.067) 0.047
23 Q53S54 CUL3 Cullin 3 1.333 ± 0.465 0.497 ± 0.145 2.123 ± 1.130 2.123 (1.254, 2.992) 0.008
24 Q6LDD1 MGMT O-6-methylguanine-DNA methyltransferase 1.081 ± 0.005 0.315 ± – 2.618 ± 1.402 2.618 (−0.863, 6.100) 0.005
25 Q6ZW64 IGH Immunoglobulin heavy locus 1.175 ± 0.453 0.528 ± 0.239 1.816 ± 0.942 1.816 (1.218, 2.415) 0.009
26 V9HVY1 FGB Fibrinogen beta chain 1.010 ± 0.153 0.719 ± 0.145 1.270 ± 0.282 1.270 (1.091, 1.449) 0.015
27 V9HW21 CA2 Carbonic anhydrase II 1.296 ± 0.205 0.901 ± 0.071 1.292 ± 0.286 1.292 (1.072, 1.512) 0.007
28 V9HWF6 ORM1 Orosomucoid 1 0.911 ± 0.235 0.472 ± 0.121 1.622 ± 0.622 1.622 (1.226, 2.017) 0.002
29 V9HWI6 GC Group-specific component (vitamin D binding protein) 0.962 ± 0.223 1.553 ± 0.497 −1.488 ± 0.456 −1.488 (−1.778, −1.198) 0.008
30 V9HWP0 APCS Amyloid P component, serum 1.067 ± 0.170 0.811 ± 0.107 1.211 ± 0.238 1.211 (1.059, 1.362) 0.048
31 X6RJP6 TAGLN2 Transgelin 2 1.074 ± 0.289 0.825 ± 0.176 1.202 ± 0.335 1.202 (0.988, 1.415) 0.017
  1. Positive value indicates up-regulation and negative value indicates down-regulation in fold change column; AICH, intracerebral hemorrhage; CI, confidence interval for mean; – indicates data missing because of no enough sample size