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Table 2 List of proteins with different abundance in AICH patients (\(\overline{\text{x}} \,{ + }\,{\text{sd}}\))

From: Identification of novel biomarker and therapeutic target candidates for acute intracerebral hemorrhage by quantitative plasma proteomics

No.

UniProt accession

Symbol

Entrez gene name

Abundance in AICH

Abundance in NC

Fold change

95% CI for fold change

P value

1

A0A024R035

C9

Complement component 9

1.087 ± 0.109

0.785 ± 0.204

1.256 ± 0.258

1.256 (1.092, 1.420)

0.016

2

A0A024R4F1

ENO1

Enolase 1, (É‘)

1.386 ± 0.582

0.952 ± 0.521

1.304 ± 0.608

1.304 (0.918, 1.690)

0.038

3

A0A087X271

CNN2

Calponin 2

1.023 ± 0.165

1.404 ± 0.134

−1.268 ± 0.278

−1.268 (−1.560, −0.977)

0.008

4

A0A0C4DFQ9

DCUN1D2

DCN1, defective in cullin neddylation 1, domain containing 2

0.571 ± 0.394

2.086 ± 0.497

−4.096 ± 4.251

−4.096 (−8.557, 0.367)

0.013

5

A2VCK8

TMSB10/TMSB4X

Thymosin beta 10

1.418 ± 0.601

0.634 ± 0.262

1.824 ± 0.994

1.824 (1.193, 2.456)

0.049

6

B4E1N5

APOL1

Apolipoprotein L, 1

1.197 ± 0.287

0.895 ± 0.266

1.225 ± 0.342

1.225 (1.007, 1.442)

0.028

7

D6RB59

EXOC3

Exocyst complex component 3

1.280 ± 0.023

0.433 ± –

2.304 ± 1.130

2.304 (−0.502, 5.109)

0.022

8

E9PN51

NDUFS8

NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23 kDa (NADH-coenzyme Q reductase)

0.906 ± 0.009

0.364 ± –

1.995 ± 0.862

1.995 (−0.146, 4.135)

0.013

9

F2RM37

F9

Coagulation factor IX

1.005 ± 0.100

0.750 ± 0.236

1.227 ± 0.258

1.227 (1.064, 1.391)

0.038

10

F8VV32

LYZ

Lysozyme

1.031 ± 0.265

1.425 ± 0.364

−1.321 ± 0.365

−1.321 (−1.553, −1.089)

0.017

11

G3V2H1

MPP5

Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)

0.586 ± 0.174

1.937 ± 0.301

−2.699 ± 1.559

−2.699 (−4.335, −1.063)

0.007

12

H7C267

PES1

Pescadillo ribosomal biogenesis factor 1

0.497 ± 0.023

2.735 ± –

−4.005 ± 2.608

−4.005 (−10.484, 2.475)

0.008

13

H7C4S2

HBP1

HMG-box transcription factor 1

0.999 ± 0.020

0.398 ± –

2.006 ± 0.872

2.006 (−0.159, 4.171)

0.025

14

L8EB32

COL14A1

Collagen, type XIV, É‘ 1

1.054 ± 0.411

2.574 ± 0.454

−2.162 ± 1.206

−2.162 (−3.428, −0.896)

0.005

15

P00739

HPR

Haptoglobin-related protein

1.106 ± 0.505

0.440 ± 0.096

2.007 ± 1.185

2.007 (1.254, 2.760)

0.046

16

P02671

FGA

Fibrinogen É‘ chain

1.050 ± 0.230

0.694 ± 0.114

1.342 ± 0.375

1.342 (1.103, 1.580)

0.026

17

P06396

GSN

Gelsolin

0.947 ± 0.096

1.367 ± 0.326

−1.321 ± 0.274

−1.321 (-1.494, −1.147)

0.003

18

P06727

APOA4

Apolipoprotein A-IV

0.796 ± 0.115

1.418 ± 0.334

−1.562 ± 0.467

−1.562 (−1.859, −1.266)

<0.001

19

P18065

IGFBP2

Insulin-like growth factor binding protein 2, 36 kDa

1.230 ± 0.238

1.742 ± 0.612

−1.327 ± 0.343

−1.327 (−1.687, −0.966)

0.041

20

P18428

LBP

Lipopolysaccharide binding protein

1.180 ± 0.309

0.700 ± 0.167

1.457 ± 0.504

1.457 (1.137, 1.778)

0.005

21

P19652

ORM2

Orosomucoid 2

0.858 ± 0.176

0.625 ± 0.110

1.248 ± 0.304

1.248 (1.055, 1.442)

0.036

22

Q08830

FGL1

Fibrinogen-like 1

0.992 ± 0.162

0.543 ± 0.087

1.552 ± 0.491

1.552 (1.036, 2.067)

0.047

23

Q53S54

CUL3

Cullin 3

1.333 ± 0.465

0.497 ± 0.145

2.123 ± 1.130

2.123 (1.254, 2.992)

0.008

24

Q6LDD1

MGMT

O-6-methylguanine-DNA methyltransferase

1.081 ± 0.005

0.315 ± –

2.618 ± 1.402

2.618 (−0.863, 6.100)

0.005

25

Q6ZW64

IGH

Immunoglobulin heavy locus

1.175 ± 0.453

0.528 ± 0.239

1.816 ± 0.942

1.816 (1.218, 2.415)

0.009

26

V9HVY1

FGB

Fibrinogen beta chain

1.010 ± 0.153

0.719 ± 0.145

1.270 ± 0.282

1.270 (1.091, 1.449)

0.015

27

V9HW21

CA2

Carbonic anhydrase II

1.296 ± 0.205

0.901 ± 0.071

1.292 ± 0.286

1.292 (1.072, 1.512)

0.007

28

V9HWF6

ORM1

Orosomucoid 1

0.911 ± 0.235

0.472 ± 0.121

1.622 ± 0.622

1.622 (1.226, 2.017)

0.002

29

V9HWI6

GC

Group-specific component (vitamin D binding protein)

0.962 ± 0.223

1.553 ± 0.497

−1.488 ± 0.456

−1.488 (−1.778, −1.198)

0.008

30

V9HWP0

APCS

Amyloid P component, serum

1.067 ± 0.170

0.811 ± 0.107

1.211 ± 0.238

1.211 (1.059, 1.362)

0.048

31

X6RJP6

TAGLN2

Transgelin 2

1.074 ± 0.289

0.825 ± 0.176

1.202 ± 0.335

1.202 (0.988, 1.415)

0.017

  1. Positive value indicates up-regulation and negative value indicates down-regulation in fold change column; AICH, intracerebral hemorrhage; CI, confidence interval for mean; – indicates data missing because of no enough sample size