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Table 3 Proteins that are significantly increased in systemic circulation 5 min after plaque disruption

From: A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption

Uniprot accession number

Protein name

Maximum fold change

ANOVA P value

Enriched in plaque

P08758

Annexin A5

2.41

0.0143

Yes

P18428

Lipopolysaccharide binding protein

1.75

0.0159

Yes

P63241

Eukaryotic translation initiation factors

2.28

0.0218

Yes

O75558

Syntaxin 11

3.04

0.0222

Yes

P00387

Cytochrome B5 reductase 3

3.88

0.0401

Yes

Q9UIB8

CD84

7.18

0.0486

No

  1. We detected 491 proteins in these plasma samples with a false discovery rate of less than 1%. After exclusion of plasma proteins that were significantly changed in the control group (those who underwent diagnostic angiography only), we identified six plasma proteins that were significantly elevated (P < 0.05) at 5 min after plaque disruption. These were cross referenced against the plaque protein library determined from plaque debris. Five of these proteins were also present in plaque debris
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Clinical Proteomics

ISSN: 1559-0275