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Table 3 Diagnostic accuracy of pulmonary nodule classifier (PNC) and individual markers evaluated in the nodule population of the validation study

From: Clinical validation of a blood-based classifier for diagnostic evaluation of asymptomatic individuals with pulmonary nodules

  Validation
CXR finding: nodule
Benign control (n = 119); Lung cancer (n = 119)
AUC [95% CI] p value
PNC 0.653 [0.583–0.723] <0.0001
Individual markers included in PNC
 CEA 0.642 [0.572–0.713] <0.0001
 CYFRA 21-1 0.628 [0.558–0.699] 0.0004
 SCC 0.567 [0.494–0.640] 0.0737
 OPN 0.535 [0.461–0.609] 0.3508
 TFPI 0.533 [0.459–0.606] 0.3815