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Table 3 Diagnostic accuracy of pulmonary nodule classifier (PNC) and individual markers evaluated in the nodule population of the validation study

From: Clinical validation of a blood-based classifier for diagnostic evaluation of asymptomatic individuals with pulmonary nodules

 

Validation

CXR finding: nodule

Benign control (n = 119); Lung cancer (n = 119)

AUC [95% CI]

p value

PNC

0.653 [0.583–0.723]

<0.0001

Individual markers included in PNC

 CEA

0.642 [0.572–0.713]

<0.0001

 CYFRA 21-1

0.628 [0.558–0.699]

0.0004

 SCC

0.567 [0.494–0.640]

0.0737

 OPN

0.535 [0.461–0.609]

0.3508

 TFPI

0.533 [0.459–0.606]

0.3815