Table 1 Proteomic changes in C57BL/6J mice on standard or high-fat diet

Plasma proteomics of 8 male C57BL/6J mice and age matched controls on standard diet at 2, 4, 8, 12, 16 and 19 months [49]

Increased

Decreased

INS

TTR

ALB

SAA1

Igκ

HP

PRDX2

Plasma proteomics of 8 male mice placed on HFD at 3 weeks of age, analyzed at 2, 4, 6, 8, 10, 12, 16 and 20 weeks after diet induction [62]

Increased

Decreased

INS

KNG

RBP-4 (isoform-specific increases and decreases)

TTR (isoform-specific increases and decreases)

APOA1 (isoform and age specific increases and decreases)

Cardiac proteomics of 5 male mice on HFD at 3 weeks of age analyzed after 8 weeks on diet [28]

Increased

Decreased

ECH1

NDPK1

TNNT2

CK

MDH2

CRYAB

ACTC1

IDH3A

AK1

ATP5B

DES1 (isoform-specific increases and decreases)

Pancreatic proteomics of 3 male mice per group started on HFD at 3 weeks, sacrificed for analysis over time at 2, 4, 8 and 16 weeks on diet [75]

Increased

Decreased

REG1

REG2

GSHPX1

Skin proteomics of 4 male mice on HFD at 3 weeks of age analyzed after 16 weeks on diet [29]

Increased

Decreased

PDI

INS

ALDOA

KRT77

APOA1

GAPDH

PRDX6

FABP

TRSF

NDPK2

APOE

MDH1

14-3-3 Protein β

PGAM1

VPS29

PSMA1

PHB

LGALS7

TTR

NDPK1

NDPK2

Keratin II, type I

CK (isoform-specific increases and decreases)

S100A10 (isoform-specific increases and decreases)

Stomach proteomics of 4 male mice on HFD at 3 weeks of age, analyzed at 16 weeks [84]

Increased

Decreased

MYL3

PEBP1

ENO1

MDH1

ATP5A1

LGALS2

PGAM1

MYL2

LGALS7

APOA1

HSPB1

ALDH3A1

FABP3

GKN1

CBR3

LDH2

PRDX2

ATP5B

TPI1 (isoform-specific increases and decreases)