The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies

Table 2 Proteomic changes in white adipose tissue of humans and WT mice

Study design	Differentially expressed proteins (gene abbreviations)
Human adipose tissue
Proteomics of 6 subcutaneous white adipose tissue depots (upper abdominal, lower abdominal, thigh, back, flank, and hip) of 6 female subjects [104]	Increased			Decreased
	HB (4 isoforms, back depot)	VIM (3 isoforms depot specific)	ENO1 (flank depot)	HPX (lower versus upper abdominal depot)
	ALB (3 isoforms, hip depot)	ATP5B (hip, flank and upper abdominal depots)	HSP 8 (upper abdominal depot, superficial layer)
	HSP-β6 (hip depot, superficial layer)	HSP-60 kDa (hip depot)	SOD (flank depot)
	FABP-4 (2 isoforms, depot and isoform specific increases and decreases)
White adipose tissue C57BL/6J mice
White adipose tissue (inguinal, retroperitoneal, mesenteric and epididymal) proteomics of 6 male mice analyzed at 12 and 24 months old [105]	Increased at 24 months		Decreased at 24 months
	ATP5B	ENO1 (2 isoforms)	CA-III (2 isoforms)	ANXA5
	PDHE1-B	IDH3α	ALB	HBB (2 isoforms)
	E-FABP	CuZn-SOD	INS	HMW adiponectin
	ERP29	PPIA	Total adiponectin
	APOA4	APOA1 (4 isoforms, 2 depot specific increases)
	VIM
	ACT

Proteomic changes in the adipose tissue of human and mouse models, showing depot and isoform specific regulation. For human adipose tissue, the significantly regulated proteins listed are those that are different between depots, not between layers of depots. Differentially expressed proteins between those layers can be found within the original text

ISSN: 1559-0275