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Table 4 Proteomic changes in the serum of acromegalic patients

From: The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies

Study design

Differentially expressed proteins (gene abbreviations)

Acromegaly

Serum proteomics of 8 acromegalic patients (3 females and 5 males), before and 3–6 months after transsphenoidal surgery [149]

Increased

Decreased

C4B

IGF-I

TTR (2 isoforms)

 

HP a2

HBB

 

APOA1 (2 isoforms)

 
  1. Significantly different changes in the serum proteome of acromegalic patients, demonstrating decreased TTR (which was also decreased in bGH mouse plasma) and increased C4B, an inflammatory marker
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Clinical Proteomics

ISSN: 1559-0275