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Table 7 Proteomic changes in the WAT of GHR−/− mice

From: The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies

Study design

Differentially expressed proteins (gene abbreviations)

GHR −/− adipose tissue

White adipose tissue (inguinal, retroperitoneal, mesenteric and epididymal) proteomics of 6 GHR−/− and WT male mice analyzed at 12 and 24 months old [166]

Increased

Decreased

EHD2 (2 isoforms)

TTR

A2M

INS

S100A10

HMW adiponectin

GLUT4

 

ADIPOQ

ANXA5 (retroperitoneal only)

 

HBB1 (24 mo only)

ACT (age and isoform specific increases and decreases)

APOA1 (age and isoform specific increases and decreases)

  1. Proteomic changes in the WAT of the GHR knockout mouse from several different depots. GHR−/− mouse WAT showed increases in adiponectin, a regulator of glucose and fatty acid oxidation, as well as decreases in proteins related to glucose homeostasis