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Table 9 Proteins regulated by several models of GH excess or deficiency

From: The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies

 

GHR−/− WAT

GHR−/− plasma

GH deficiency

rhGH doping serum

bGH plasma

Acromegaly serum

HFD tissues

HFD plasma

Aging plasma

Aging WAT

APOA1

↓

 

↑

↓

 

↓

↑ skin, stomach

  

↑

APOE

 

↓

  

↑

 

↑ Skin

   

APOA4

 

↑

       

↑

TTR

↑

  

↑

↓

↓

 

↑

↑

↑

HP

 

↓

↓

 

↑

↓

  

↑

 

HBB

↑

  

↓

     

↓

RBP4

 

↑

  

↓

  

↑

  

A2M

↓

   

↑↓

     
  1. Shared proteins regulated by mouse or human models of GH excess or deficiency, including several apolipoproteins and inflammatory markers. Upward-pointing arrows indicate increased expression, whereas downward-pointing arrows indicate decreased expression. Arrows in both directions represent isoform-specificity, with total levels of the protein unchanged