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Table 1 Proteins that increased in MSC in response to IFN-γ treatment

From: Interferon γ induced compositional changes in human bone marrow derived mesenchymal stem/stromal cells

ID Gene Description Donor
4 69 74 140 150
(A)        
 Q5T3U5 ABCC10 Multidrug resistance-associated protein 7 1.3 CTL CTL CTL IFN
 Q9UPQ3 AGAP1 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 4.3 6.3 CTL 4.0 0.8
 Q9ULJ7 ANKRD50 Ankyrin repeat domain-containing protein 50 1.8 1.0 5.5 3.8 3.3
 Q6ZW76 ANKS3 Ankyrin repeat and SAM domain-containing protein 3 CTL CTL CTL 0.6 CTL
 Q8NCL9 APCDD1L Protein APCDD1-like CTL 2.4 CTL 1.9 3.0
 Q9BSF8 BTBD10 BTB/PoZ domain-containing protein 10 CTL CTL CTL CTL CTL
 Q8N5S9 CAMKK1 Calcium/calmodulin-dependent protein kinase kinase 1 CTL CTL 0.8 3.9 CTL
 P49674 CSNK1E Casein kinase I isoform epsilon 4.2 6.9 1.4 CTL 5.3
 Q9Y6M4 CSNK1G3 Casein kinase I isoform gamma-3 CTL CTL 1.1 CTL CTL
 P39880 CUX1 Homeobox protein cut-like 1 1.1 CTL CTL 13.7 CTL
 Q9H8V3 ECT2 Protein ECT2 CTL CTL 1.6 3.7 1.6
 O95864 FADS2 Fatty acid desaturase 2 8.3 4.2 4.5 2.2 1.7
 P02671 FGA Fibrinogen alpha chain CTL CTL 73.9 0.5 4.4
 P02679 FGG Fibrinogen gamma chain 18.9 CTL 42.8 0.4 3.0
 Q9NYZ3 GTSE1 G2 and S phase-expressed protein 1 CTL CTL CTL CTL 4.0
 Q9Y2K7 KDM2A Lysine-specific demethylase 2A 5.4 0.3 1.1 CTL 6.4
 Q9BVG8 KIFC3 Kinesin-like protein KIFC3 5.2 CTL CTL 1.5 CTL
 Q659C4 LARP1B La-related protein 1B 3.5 CTL CTL CTL CTL
 Q15013 MAD2L1BP MAD2L1-binding protein CTL CTL CTL 0.7 CTL
 Q07864 POLE DNA polymerase epsilon catalytic subunit A CTL CTL 3.5 CTL 1.1
 Q9P2K3 RCOR3 REST Corepressor 3 CTL CTL CTL CTL CTL
 O15541 RNF113A RING finger protein 113A 1.2 1.2 CTL 18.5 4.8
 Q9GZN7 ROGDI Protein rogdi homolog CTL 0.0 CTL CTL 1.8
 Q99719 SEPT5 Septin-5 4.8 CTL CTL CTL 0.5
 O95359 TACC2 Transforming acidic coiled-coil-containing protein 2 CTL CTL CTL CTL CTL
 O15040 TECPR2 Tectonin beta-propeller repeat-containing protein 2 2.0 3.8 CTL 6.3 0.8
 Q9P273 TENM3 Teneurin-3 3.9 CTL 3.2 2.1 1.3
 Q86SZ2 TRAPPC6B Trafficking protein particle complex subunit 6B 0.3 CTL CTL CTL
 Q8IWR1 TRIM59 Tripartite motif-containing protein 59 CTL 3.2 4.0 CTL 0.9
 Q9NPG3 UBN1 Ubinuclein-1 CTL CTL CTL CTL CTL
 P62068 USP46 Ubiquitin carboxyl-terminal hydrolase 46 CTL CTL 1.5 CTL CTL
 Q5ST30 VARS2 Valine–tRNA ligase, mitochondrial CTL CTL 1.9 3.5 CTL
 Q9Y2K1 ZBTB1 Zinc finger and BTB domain-containing protein 1 0.5 CTL CTL 7.3 CTL
 Q9ULJ6 ZMIZ1 Zinc finger MIZ domain-containing protein 1 4.6 CTL CTL 1.6 CTL
(B)        
 Q9HCE6 ARHGEF10L Rho guanine nucleotide exchange factor 10-like protein IFN IFN IFN
 Q6ICH7 ASPHD2 Aspartate beta-hydroxylase domain-containing protein 2 IFN IFN IFN
 Q8WXX7 AUTS2 Autism susceptibility gene 2 protein IFN IFN IFN
 Q9BX70 BTBD2 BTB/POZ domain-containing protein 2 2.6 4.3 3.2 IFN
 Q5VU97 CACHD1 VWFA and cache domain-containing protein 1 1.8 IFN IFN IFN IFN
 Q9BSQ5 CCM2 Cerebral cavernous malformations 2 protein 2.6 3.9 3.4 0.5 3.7
 Q86YQ8 CPNE8 Copine-8 4.4 5.4 2.0 3.5 1.9
 Q5H9U9 DDX60L Probable ATP-dependentRNA helicase DDX60-like IFN IFN IFN 8.1 8.2
 Q96C10 DHX58 Probable ATP-dependentRNA helicase DHX58 IFN IFN IFN IFN IFN
 Q96J88 EPSTI1 Epithelial-stromal interaction protein 1 IFN IFN IFN IFN IFN
 Q9BTL3 FAM103A1 RNMT-activating mini protein IFN IFN IFN
 Q96MK3 FAM20A Pseudokinase FAM20A 5.0 10.0 4.9 IFN IFN
 Q8IXL6 FAM20C Extracellular serine/threonine protein kinase FAM20C IFN 1.0 IFN 11.1 IFN
 Q13480 GAB1 GRB2-associated-binding protein 1 IFN 2.2 4.8 IFN
 Q14435 GALNT3 Polypeptide N-acetylgalactosaminyltransferase 3 IFN 12.1 8.5 3.6 IFN
 P36269 GGT5 Gamma-glutamyltransferase 5 6.2 1.0 16.8 2.5 IFN
 Q13547 HDAC1 Histone deacetylase 1 6.8 1.9 3.6 4.7 0.8
 P01112 HRAS GTPase HRas 13.6 1.4 1.2 4.1 IFN
 P01579 IFNG Interferon gamma IFN IFN IFN IFN
 Q13572 ITPK1 Inositol-tetrakisphosphate 1-kinase IFN 3.9 2.5 1.6 3.0
 Q16363 LAMA4 Laminin subunit alpha-4 1.9 2.4 3.2 3.4 12.1
 Q14392 LRRC32 Leucine-rich repeat-containing protein 32 IFN IFN IFN IFN
 P11137 MAP2 Microtubule-associated protein 2 IFN IFN IFN
 Q96DP5 MTFMT Methionyl-tRNA formyltransferase, mitochondrial IFN IFN IFN
 O75113 N4BP1 NEDD4-binding protein 1 3.5 2.0 2.1 4.6 3.5
 Q7Z2Y5 NRK Nik-related protein kinase IFN IFN IFN
 Q9Y5H3 PCDHGA10 Protocadherin gamma-A10 IFN IFN IFN
 Q9H4M7 PLEKHA4 Pleckstrin homology domain-containing family A member 4 IFN IFN IFN 4.7 IFN
 Q16647 PTGIS Prostacyclin synthase IFN 1.3 52.2 37.4 2.0
 P35354 PTGS2 Prostaglandin G/H synthase 2 IFN IFN IFN
 Q15262 PTPRK Receptor-type tyrosine-protein phosphatase kappa 4.5 2.1 5.7 4.2 3.3
 P05120 SERPINB2 Plasminogen activator inhibitor 2 IFN IFN IFN 1.0 CTL
 P22732 SLC2A5 Solute carrier family 2, facilitated glucose transporter member 5 IFN IFN IFN
 P84022 SMAD3 Mothers against decapentaplegic homolog 3 4.2 0.2 5.9 4.6 1.5
 Q9BXI6 TBC1D1 TBC1 domain family member 1 3.8 IFN 10.0 1.5 2.6
 Q9BXS4 TMEM59 Transmembrane protein 59 4.9 IFN IFN 0.9
 Q9BVA1 TUBB2B Tubulin beta-2B chain 0.8 1.5 IFN 65.6 IFN
 P22415 USF1 Upstream stimulatory factor 1 IFN IFN IFN
 O75317 USP12 Ubiquitin carboxyl-terminal hydrolase 12 IFN IFN 2.2 IFN
 Q702N8 XIRP1 Xin actin-binding repeat-containing protein 1 IFN IFN IFN IFN 7.3
 Q9HCC9 ZFYVE28 Lateral signaling target protein 2 homolog IFN IFN IFN
  1. Proteins that were increased following interferon treatment with transcripts that are (A) designated as IFN-γ responsive or (B) not designated as IFN-γ responsive. Results are presented as fold increase following 20 h of IFN-γ treatment. IFN indicates only detected in interferon treated cells. CTL indicates only detected in untreated cells. – indicates not detected in indicated donor sample