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Table 2 List of the 25 proteins with the highest fold-change between IgAN with versus without progression, only significantly changed proteins included in list

From: Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy

UniProtKB accession

N unique peptides

Protein name

Fold change

p value

O00391

4

Sulfhydryl oxidase 1

3.33

0.004

P13671

16

Complement C6

2.95

0.0003

P10643

14

Complement C7

2.65

0.001

P08519

7

Apolipoprotein(a)

2.58

0.004

P11215

4

Integrin alpha-M

2.56

0.03

P00736

2

Complement C1r subcomponent

2.53

0.001

P01876

21

Ig alpha-1 chain C region

2.35

0.02

P01019

4

Angiotensinogen

2.26

0.03

P68032

2

Actin, alpha cardiac muscle 1

2.21

0.02

P0C0L5

5

Complement C4-B

2.20

0.01

Q9GIY3

2

HLA class II histocompatibility antigen, DRB1-14 beta chain

2.16

0.05

P22102

4

Trifunctional purine biosynthetic protein adenosine-3

2.07

0.002

P04114

32

Apolipoprotein B-100

2.01

0.04

P07358

14

Complement C8 beta chain

1.97

0.01

P07357

19

Complement C8 alpha chain

1.97

0.001

P01031

39

Complement C5

1.93

0.01

Q9HCU0

2

Endosialin

1.87

0.05

P04003

14

C4b-binding protein alpha chain

1.86

0.01

P31947

2

14-3-3 protein sigma

1.84

0.03

P07225

3

Vitamin K-dependent protein S

1.84

0.03

P36980

3

Complement factor H-related protein 2

1.84

0.003

O15143

7

Actin-related protein 2/3 complex subunit 1B

1.83

0.03

Q15063

10

Periostin

1.79

0.04

Q9BXR6

22

Complement factor H-related protein 5

1.79

0.01

Q9BY44

2

Eukaryotic translation initiation factor 2A

1.76

0.03

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Clinical Proteomics

ISSN: 1559-0275