Proteomic profiling identifies markers for inflammation-related tumor–fibroblast interaction

Table 1 Proteins of mainly stromal origin that are increased in abundance

Acc.	Gene names	MP significant	Tumor versus normal		High versus low		Low versus normal		SC (Isella et al. 2015)
Acc.	Gene names	MP significant	log2FC	p value	log2FC	p value	log2FC	p value	SC (Isella et al. 2015)
Q14767	LTBP2	+	3.941	0.000	− 0.228	0.759	4.056	0.000	0.986
P35442	THBS2	+	3.015	0.004	− 3.233	0.064	4.631	0.000	0.737
P17813	ENG	+	2.313	0.000	− 0.945	0.204	2.786	0.000	0.797
P27658	COL8A1	+	2.186	0.019	− 1.392	0.330	2.882	0.021	1.000
Q12884	FAP	+^a	2.162	0.035	− 3.840	0.031	4.083	0.002	0.896
Q99715	COL12A1	+	2.100	0.002	− 1.027	0.266	2.614	0.003	0.994
Q16270	IGFBP7	+	2.071	0.000	− 0.850	0.379	2.496	0.000	0.996
Q96D15	RCN3	+	2.061	0.000	− 0.607	0.340	2.365	0.002	0.746
P09486	SPARC	+	1.943	0.010	0.145	0.918	1.870	0.052	0.983
Q9Y4K0	LOXL2	+	1.809	0.003	− 1.260	0.218	2.439	0.001	0.975
Q8IUX7	AEBP1	+	1.741	0.000	− 0.698	0.256	2.090	0.002	0.931

Positive identified proteins that were significantly increased greater than threefold with p < 0.05 (2-sided t test) and a stromal contribution of > 50% are shown. Normal, normal adjacent mucosa; tumor, tumor tissue; High, high stage tumor samples; low, low stage tumor samples; SC, stromal contribution. Stromal contribution reprinted by permission from Macmillian Publishers Ltd: Nature Genetics (47: 312–319), copyright (2015)
^aOnly low-stage versus normal is MP significant

ISSN: 1559-0275