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Table 2 Alterations in ECM constituents

From: Proteomic profiling identifies markers for inflammation-related tumor–fibroblast interaction

Acc.

Gene names

MP significant

Tumor versus normal

High versus low

Low versus normal

SC (Isella et al. 2015)

log2FC

p value

log2FC

p value

log2FC

p alue

P27658

COL8A1

+

2.186

0.019

− 1.392

0.330

2.882

0.021

1.000

Q12884

FAP

+a

2.162

0.035

− 3.840

0.031

4.083

0.002

0.896

Q99715

COL12A1

+

2.100

0.002

− 1.027

0.266

2.614

0.003

0.994

Q13751

LAMB3

+

2.091

0.000

0.691

0.226

1.745

0.010

0.003

Q9Y4K0

LOXL2

+

1.809

0.003

− 1.260

0.218

2.439

0.001

0.975

A8TX70

COL6A5

+

− 1.778

0.007

0.800

0.312

− 2.178

0.007

0.981

Q05707

COL14A1

+

− 1.730

0.001

0.813

0.215

− 2.137

0.000

0.996

P55268

LAMB2

+

− 1.798

0.003

− 0.358

0.662

− 1.619

0.044

0.145

Q2UY09

COL28A1

+

− 2.288

0.006

0.377

0.701

− 2.476

0.026

0.396

Q07507

DPT

+

− 2.477

0.000

0.762

0.095

− 2.858

0.000

0.908

P07585

DCN

+

− 2.754

0.000

0.795

0.334

− 3.151

0.000

0.823

Q9BXN1

ASPN

+

− 2.929

0.001

− 0.857

0.571

− 2.501

0.020

0.994

  1. The table shows proteins that are ECM constituents or involved in extra cellular matrix modulation. Negative values indicate higher abundance in normal, positive values higher in tumor samples. Normal, normal adjacent mucosa; tumor, tumor tissue; High, high stage tumor samples; low, low stage tumor samples; SC, stromal contribution. Stromal contribution reprinted by permission from Macmillian Publishers Ltd: Nature Genetics (47: 312–319), copyright (2015)
  2. aOnly low-stage versus normal is MP significant