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Table 5 Comparison of Proseek® values obtained from women with early stage ovarian cancer versus benign disease

From: A multiplex platform for the identification of ovarian cancer biomarkers

Protein Early versus benign
AUC (95% CI) Rank Sensitivity at 95% specificity (95% CI) Rank
HE4 0.87 (0.76, 0.96) 1 0.6 (0.37, 0.88) 1
CA.125 0.87 (0.73, 0.97) 2 0.46 (0.13, 0.93) 3
hK11 0.79 (0.67, 0.89) 3 0.38 (0.15, 0.65) 9
PRSS8 0.78 (0.64, 0.89) 4 0.44 (0.2, 0.7) 4
IL.6 0.75 (0.65, 0.86) 5 0.54 (0.28, 0.7) 2
MK 0.72 (0.57, 0.85) 6 0.37 (0.13, 0.61) 11
CXCL13 0.71 (0.53, 0.85) 7 0.39 (0.16, 0.66) 7
CXCL10 0.71 (0.57, 0.85) 8 0.35 (0.14, 0.62) 13
EZR 0.7 (0.55, 0.83) 9 0.33 (0.11, 0.56) 14
CSTB 0.7 (0.53, 0.85) 10 0.21 (0.01, 0.62) 23
FR.alpha 0.69 (0.56, 0.81) 11 0.39 (0.08, 0.62) 8
VEGF.A 0.69 (0.52, 0.84) 12 0.37 (0.19, 0.6) 10
KLK6 0.69 (0.54, 0.8) 13 0.41 (0.11, 0.63) 5
FUR 0.68 (0.53, 0.83) 14 0.16 (0.04, 0.42) 34
CSF.1 0.68 (0.5, 0.83) 15 0.14 (0.01, 0.41) 42
AM 0.68 (0.5, 0.82) 16 0.26 (0.07, 0.54) 18
LYN 0.67 (0.56, 0.79) 17 0.39 (0.05, 0.59) 6
ICOSLG 0.67 (0.51, 0.82) 18 0.19 (0.02, 0.47) 28
CDH3 0.67 (0.51, 0.83) 19 0.35 (0.21, 0.6) 12
CXCL9 0.66 (0.49, 0.82) 20 0.28 (0.09, 0.57) 16
ILT.3 0.66 (0.5, 0.82) 21 0.17 (0.02, 0.49) 32
GDF.15 0.66 (0.49, 0.84) 22 0.1 (0, 0.54) 51
IFN.gamma 0.65 (0.5, 0.79) 23 0.26 (0.01, 0.55) 17
EGFR 0.65 (0.49, 0.8) 24 0.1 (0.01, 0.37) 56
MCP.1 0.65 (0.48, 0.81) 25 0.09 (0, 0.36) 58
  1. The 25 proteins with the highest AUC values were ranked for discriminating early stage high grade serous ovarian cancer versus benign ovarian disease. Their ranking for sensitivity at 95% specificity is also provided. Data for all 92 proteins is provided in Additional file 5