Table 2 Thirty-nine proteins with decreased expression in the vitreous of idiopathic macular holes compared with controls
From: A proteomic approach to understanding the pathogenesis of idiopathic macular hole formation
Protein name | Gene | neXtProt ID | Function |
|---|---|---|---|
Stromelysin-1 | MMP3 | P08254 | Degrades fibronectin; involved in breakdown and remodeling of ECM proteins |
Transforming growth factor-β-induced protein ig-h3 | TGFBI | Q15582 | Plays a role in cell adhesion; involved in cell–collagen interactions |
T-complex protein 1 subunit zeta | CCT6A | P40227 | Molecular chaperone; assists in the folding of proteins, including actin and tubulin |
RNA-binding protein 43 | RBM43 | Q6ZSC3 | Nucleotide and RNA binding |
Vimentin | VIM | P08670 | Class-III intermediate filament; normal component of vitreous |
Pro-neuregulin-1, membrane-bound isoform | NRG1 | Q02297 | Tyrosine kinase activator activity; ligand for integrins |
α-Crystallin B chain | CRYAB | P02511 | Normal component of vitreous, lens, cornea; molecular chaperone |
α-Crystallin A chain | CRYAA | P02489 | Normal component of vitreous, lens, cornea; molecular chaperone |
Mixed lineage kinase domain-like protein | MLKL | Q8NB16 | Pseudokinase with role in TNF-induced necroptosis, a programmed cell death process |
Retinal dehydrogenase 1 | ALDH1A1 | P00352 | Converts retinaldehyde to retinoic acid; binds retinal |
Heat shock protein β-1 | HSPB1 | P04792 | Involved in stress resistance and actin organization |
Lipocalin-1 | LCN1 | P31025 | Cysteine-type endopeptidase inhibitor activity |
Phosphoglycerate kinase 1 | PGK1 | P00558 | Glycolytic enzyme |
CLOCK-interacting pacemaker | CIPC | Q9C0C6 | Transcriptional repressor |
Glucoside xylosyltransferase 2 | GXYLT2 | A0PJZ3 | Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose |
Carbonic anhydrase 1 | CA1 | P00915 | Reversible hydration of carbon dioxide |
Leucine-rich repeat and IQ domain-containing protein 3 | LRRIQ3 | A6PVS8 | Protein binding |
Transgelin-2 | TAGLN2 | P37802 | Regulates cell migration; cadherin binding involved in cell–cell adhesion |
β-Crystallin A3 | CRYBA1 | P05813 | Normal component of vitreous, lens, cornea |
Decorin | DCN | P07585 | Extracellular matrix binding; glycosaminoglycan binding; may affect rate of fibrils formation |
Tetraspanin-16 | TSPAN16 | Q9UKR8 | Cell surface receptor signaling pathway |
Taste receptor type 2 member 9 | TAS2R9 | Q9NYW1 | Taste receptor activity |
SLIT and NTRK-like protein 3 | SLITRK3 | O94933 | Suppresses neurite outgrowth; axonogenesis |
β-Crystallin B2 | CRYBB2 | P43320 | Normal component of vitreous, lens, cornea |
DNA-directed RNA polymerase III subunit RPC2 | POLR3B | Q9NW08 | Contributes to RNA polymerase III activity |
55 kDa erythrocyte membrane protein | MPP1 | Q00013 | Regulates neutrophil polarity |
α-Enolase | ENO1 | P06733 | Plays a role in glycolysis; role in fibrinolytic system as receptor and activator of plasminogen; cadherin binding involved in cell–cell adhesion |
Heat shock 70 kDa protein 1A | HSPA1A | P0DMV8 | Stabilizes preexistent proteins against aggregation in cooperation with other chaperones |
Apolipoprotein D | APOD | P05090 | Lipid transport |
Filamin-A | FLNA | P21333 | Involved in actin filament binding; promotes orthogonal branching of actin filaments; links actin filaments to membrane glycoproteins |
Myocilin | MYOC | Q99972 | Secreted glycoprotein that regulates activation of different signaling pathways involved in cell adhesion, cell–matrix adhesion, cytoskeleton organization, and cell migration; binds with fibronectin |
UDP-glucose:glycoprotein glucosyltransferase 2 | UGGT2 | Q9NYU1 | Recognizes glycoproteins with minor folding defects; provide quality control for protein folding in the endoplasmic reticulum |
Uncharacterized protein C1orf167 | C1orf167 | Q5SNV9 | Unknown |
Vinculin | VCL | P18206 | Actin filament binding protein involved in cell matrix adhesion and cell–cell adhesion; regulates cell-surface E-cadherin expression |
Dynein heavy chain 1, axonemal | DNAH1 | Q9P2D7 | Cilium movement involved in cell motility |
β-Actin-like protein 2 | ACTBL2 | Q562R1 | Major constituent of the contractile apparatus |
Tectonic-1 | TCTN1 | Q2MV58 | Cilium assembly |
Hemoglobin subunit β | HBB | P68871 | Oxygen transport; contributes to haptoglobin binding |
Potassium voltage-gated channel subfamily G member 1 | KCNG1 | Q9IUX4 | Potassium channel activity |