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Table 4 The Distribution of the ≥ 510 gene symbols observed from the endogenous tryptic peptides of normal human plasma identified by X!TANDEM with respect to the human Gene Ontology (GO) Cellular Component as computed by STRING V10

From: The proteins cleaved by endogenous tryptic proteases in normal EDTA plasma by C18 collection of peptides for liquid chromatography micro electrospray ionization and tandem mass spectrometry

Term

Number of genes

p-value

p-value_fdr

p-value_bonferroni

Proteinaceous extracellular matrix

45

5.01E−24

7.94E−21

7.94E−21

Extracellular matrix

46

1.40E−22

1.11E−19

2.23E−19

Endoplasmic reticulum lumen

35

8.55E−22

4.51E−19

1.35E−18

Extracellular matrix component

28

3.25E−21

1.29E−18

5.15E−18

Collagen trimer

26

6.35E−21

2.01E−18

1.01E−17

Fibrillar collagen trimer

11

5.07E−17

1.34E−14

8.03E−14

Organelle lumen

153

2.79E−14

6.31E−12

4.42E−11

Intracellular organelle lumen

151

4.04E−14

8.00E−12

6.40E−11

Organelle part

220

5.07E−12

8.03E−10

8.03E−09

Basement membrane

16

3.64E−11

5.25E−09

5.77E−08

Intracellular organelle part

213

4.77E−11

6.30E−09

7.56E−08

Complex of collagen trimers

7

9.77E−11

1.19E−08

1.55E−07

Cytoplasm

255

1.75E−10

1.98E−08

2.78E−07

Organelle

277

1.33E−08

1.41E−06

2.11E−05

Endoplasmic reticulum part

51

3.26E−08

3.23E−06

5.17E−05

Intracellular organelle

259

4.64E−08

4.32E−06

7.35E−05

Intracellular

280

8.51E−08

7.49E−06

1.35E−04

Endoplasmic reticulum

62

1.59E−07

1.32E−05

2.52E−04

Cytoplasmic part

185

4.20E−07

3.33E−05

6.65E−04

Endomembrane system

108

4.90E−07

3.70E−05

7.76E−04

Intracellular part

276

5.95E−07

4.28E−05

9.42E−04

Membrane-bounded organelle

263

9.38E−07

6.46E−05

1.49E−03

Network-forming collagen trimer

4

1.25E−06

7.92E−05

1.98E−03

Collagen network

4

1.25E−06

7.92E−05

1.98E−03

Macromolecular complex

124

2.06E−06

1.25E−04

3.26E−03

Basement membrane collagen trimer

4

3.68E−06

2.16E−04

5.84E−03

Extracellular region part

112

5.58E−06

3.16E−04

8.85E−03

Protein complex

110

5.79E−06

3.16E−04

9.18E−03

Intracellular membrane-bounded organelle

238

6.50E−06

3.43E−04

1.03E−02

Collagen type V trimer

3

1.14E−05

5.81E−04

1.80E−02

  1. The headings are exactly as supplied by STRING. The Filtered (Filter 2) data can be found in Additional file 1, Additional file 2, Additional file 3, Additional file 4