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Table 5 The Distribution of the ≥ 510 gene symbols observed from the endogenous tryptic peptides of normal human plasma with at least 5 peptides by X!TANDEM with respect to the human KEGG pathway as computed by STRING V10

From: The proteins cleaved by endogenous tryptic proteases in normal EDTA plasma by C18 collection of peptides for liquid chromatography micro electrospray ionization and tandem mass spectrometry

Term

Number of genes

p-value

p-value_fdr

p-value_bonferroni

Protein digestion and absorption

26

7.78E−23

2.23E−20

2.23E−20

ECM-receptor interaction

19

3.79E−14

5.44E−12

1.09E−11

Focal adhesion

23

2.04E−10

1.95E−08

5.85E−08

Amoebiasis

16

1.47E−09

1.06E−07

4.22E−07

Platelet activation

16

2.51E−08

1.44E−06

7.22E−06

PI3K-Akt signaling pathway

25

2.02E−07

9.67E−06

5.80E−05

  1. A total of 1165 protein interactions were observed (expected 590) from 461 gene symbols proteins that showed a probability of much less than p < 0.0001. The headings are exactly as supplied by STRING. The Filtered (Filter 2) data can be found in Additional file 1, Additional file 2, Additional file 3, Additional file 4