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Table 3 All up-regulated proteins in the CA-SA ST398 group

From: Distinct virulent network between healthcare- and community-associated Staphylococcus aureus based on proteomic analysis

Uniprot acc no. Prot_description FC* (398/239) P value
Known virulence-related factors
D2N8W5 AgrC** 23.91 0.01
D2N8W6 AgrA 7.20 0.02
D2N7I3 SrrB 2.02 0.02
D2N8Z3 SigB 1.98 0.03
D2N718 Conserved virulence factor B (SAPIG1392) 1.98 0.02
D2N5H5 ClpP 1.77 0.02
Transcriptional regulator
D2N576 SarX 9.91 0.01
D2N9W6 AraC family regulatory protein 4.48 0.01
D2N9P8 Phosphosugar-binding transcriptional regulator, RpiR family 3.99 0.02
D2N3I9 Transcriptional regulator, GntR family 3.32 0.02
D2N9Q7 Phosphosugar-binding transcriptional regulator 3.07 0.03
D2N823 PhoP 2.36 0.02
D2N6S6 Glycerol uptake operon antiterminator regulatory protein 2.41 0.03
D2N8K6 RecX 2.08 0.04
Arginine and proline metabolism
D2NAL7 ArcA 6.11 0.03
D2NAL6 ArcB 4.18 0.02
D2NAL4 ArcC 2.52 0.03
Multidrug resistance
D2N9T7 Multidrug resistance protein A 4.72 0.02
D2N552 Multidrug resistance ABC transporter ATP-binding and permease protein 3.84 0.02
Two-component system
D2N9Y1 NarH 2.36 0.03
D2N361 YycG 1.89 0.03
Pyrimidine metabolism
D2NAJ6 NrdD 11.84 0.02
D2N6H8 PyrE 2.36 0.02
D2N6H3 PyrB 2.11 0.04
D2N942 Upp 1.52 0.02
Pyruvate metabolism
D2N3S5 PflB 2.37 0.04
D2N9V0 Mqo 2.26 0.02
D2N7L8 AccC 1.78 0.02
Histidine metabolism
D2N9R5 HutU 17.44 0.01
D2N9R4 HutI 3.59 0.02
D2N9R7 HutG 1.82 0.04
Glycolysis/gluconeogenesis
D2NAA0 Fbp 2.63 0.02
D2N9Z9 GpmA 2.50 0.02
D2N8B5 PckA 2.34 0.02
Other known proteins
D2N3K5 CapC 21.85 0.01
D2N3F9 Antigen, 67 kDa 11.84 0.05
D2N5J2 Probable membrane protein 8.22 0.01
D2NA54 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase) 7.79 0.01
D2N5B9 QueC 6.59 0.01
D2N3D6 Amidohydrolase 2 6.51 0.02
D2N543 Iron dependent repressor 6.42 0.02
D2N8W0 Nitroreductase family protein 6.12 0.02
D2N628 Acetyl transferase 5.96 0.02
D2NA36 Para-nitrobenzyl esterase 5.36 0.02
D2N4R9 FolP 4.83 0.02
D2N3T8 ABC transporter, substrate-binding protein 4.82 0.02
D2N549 Teichoic acid biosynthesis protein X 4.81 0.01
D2N944 UPF0340 protein 4.72 0.02
D2N4D0 Stage 0 sporulation protein J 4.54 0.01
D2N5Q4 Cytosol aminopeptidase family protein 4.53 0.04
D2N4P0 Stage 0 sporulation protein YaaT 3.98 0.02
D2N526 Hydrolase, alpha/beta hydrolase fold family 3.92 0.02
D2N723 DapB 3.80 0.02
D2N3Q0 Pts system eiibc component 3.71 0.02
D2N8G9 ABC transporter EcsB 3.67 0.01
D2N3F6 Aminoacylase 3.58 0.02
D2N585 Lipoprotein, putative 3.47 0.02
D2N6B0 SpoU rRNA Methylase family protein 3.42 0.02
D2N349 NnrD 3.39 0.02
D2NAA6 Glyoxalase family protein 3.37 0.02
D2N362 YycH protein 3.21 0.03
D2N6F0 UPF0747 protein 3.18 0.02
D2N3K2 Aldehyde-alcohol dehydrogenase 2 3.12 0.02
D2N9Q3 Phosphoglycolate phosphatase 3.04 0.02
D2N411 ABC transporter, permease protein 3.01 0.02
D2N7J1 Asppase 2.69 0.03
D2N7R6 NfeD 2.63 0.01
D2N4E3 Phosphoglycerate mutase family protein 2.59 0.02
D2N7R2 PhoH family protein 2.55 0.02
D2N5I8 Rnr 2.52 0.02
D2N7Z5 Tag 2.48 0.02
D2N9Z1 Zinc-binding lipoprotein AdcA 2.47 0.04
D2N4S0 FolB 2.41 0.04
D2N363 YycI protein 2.39 0.02
D2NA39 ABC transporter ATP-binding protein 2.36 0.04
D2N499 NAD-dependent epimerase/dehydratase 2.36 0.02
D2N6R1 PgsA 2.34 0.02
D2N5Y1 NadK 2.34 0.02
D2N804 EngB 2.18 0.02
D2N421 NanE 2.15 0.04
D2N6C3 MurI 2.12 0.02
D2N356 DHH subfamily 1 protein 2.11 0.02
D2N8M1 Map 2.10 0.02
D2N5H2 UPF0042 nucleotide-binding protein 2.10 0.03
D2N7R9 Ribosomal RNA small subunit methyltransferase E 2.10 0.01
D2N870 Ftsk/spoiiie family protein 2.09 0.02
D2N9Y2 Nitrate reductase, alpha subunit 2.04 0.02
D2N5V8 FabH 1.95 0.02
D2NA13 ABC transporter, ATP-binding/permease protein 1.92 0.04
D2N6V0 Cardiolipin synthetase (Cardiolipin synthase) (CLsynthase) 1.92 0.03
D2N6W2 Catalase 1.90 0.02
D2N8Q5 Aldehyde dehydrogenase 1.87 0.02
D2N558 DhaK 1.86 0.04
D2N9V4 TpgX protein 1.84 0.02
D2N860 Fhs 1.82 0.02
D2N8R8 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase 1.80 0.04
D2N5D0 ABC transporter permease protein 1.80 0.04
D2N7M6 GcvPB 1.80 0.04
D2N694 Glycerophosphoryl diester phosphodiesterase 1.79 0.02
D2N634 QoxB 1.78 0.02
D2N4Q0 IspE 1.78 0.02
D2N727 LysA 1.77 0.02
D2N6R4 Rny 1.74 0.02
D2N9L2 ModA 1.71 0.03
D2N5F5 DegV family protein 1.69 0.02
D2N520 Iron-binding protein 1.66 0.04
D2N9C8 Alcohol dehydrogenase, zinc-binding domain protein 1.64 0.02
D2N359 PurA 1.64 0.04
D2N6G7 IleS 1.62 0.02
D2N9V2 TagF domain protein 1.61 0.02
D2N6Y5 Transcription antiterminator 1.60 0.04
D2N7P9 ATP-dependent RNA helicase 1.60 0.02
D2N4Q1 PurR 1.58 0.02
D2N5F8 Ribosomal subunit interface protein 1.57 0.02
D2N662 Potassium uptake protein TrkA 1.57 0.02
D2N9C5 Conserved domain protein 1.57 0.02
D2N7J7 Zwf 1.56 0.03
D2N3I0 Acetoin(Diacetyl) reductase (Acetoin dehydrogenase) 1.55 0.02
D2N780 AsnS 1.53 0.02
D2N8B2 2,5-diketo-D-gluconic acid reductase A 1.52 0.02
D2N5Q3 YumB 1.52 0.02
D2N6S5 MutL 1.52 0.03
D2N6M8 TopA 1.52 0.04
D2N523 Hydrolase, alpha/beta hydrolase fold family 1.51 0.02
D2N4S2 LysS 1.51 0.02
Unknown proteins
D2N9S7 Uncharacterized protein 9.98 0.02
D2N965 Uncharacterized protein 8.45 0.01
D2N3Y5 Uncharacterized protein 5.51 0.02
D2N899 Uncharacterized protein 4.17 0.02
D2N9W5 Uncharacterized protein 3.98 0.01
D2N4F3 Uncharacterized protein 3.92 0.03
D2N692 Uncharacterized protein 3.24 0.05
D2N5Y6 Uncharacterized protein 2.69 0.02
D2N5H8 Uncharacterized protein 2.65 0.02
D2N8E4 Uncharacterized protein 2.60 0.02
D2N678 Uncharacterized protein 2.58 0.02
D2N6V3 Uncharacterized protein 2.15 0.02
D2N9T5 Uncharacterized protein 2.07 0.04
D2N8T9 Uncharacterized protein 2.03 0.04
D2N8R7 Uncharacterized protein 1.89 0.02
D2N8B3 Uncharacterized protein 1.65 0.02
D2N6R0 Uncharacterized protein 1.64 0.03
D2N9C6 Uncharacterized protein 1.58 0.02
D2N971 Uncharacterized protein 1.56 0.02
D2N5K3 Uncharacterized protein 1.67 0.03
  1. *The calculation of FC (398/239) in this table is dividing the average value of peptide mass of proteins in ST398 strains by that average value in ST239 strains
  2. **Bold italics in this table is used to highlight the selected significantly differentially expressed genes for CA-SA ST398 up-regulated network construction