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Table 3 All up-regulated proteins in the CA-SA ST398 group

From: Distinct virulent network between healthcare- and community-associated Staphylococcus aureus based on proteomic analysis

Uniprot acc no.

Prot_description

FC* (398/239)

P value

Known virulence-related factors

D2N8W5

AgrC**

23.91

0.01

D2N8W6

AgrA

7.20

0.02

D2N7I3

SrrB

2.02

0.02

D2N8Z3

SigB

1.98

0.03

D2N718

Conserved virulence factor B (SAPIG1392)

1.98

0.02

D2N5H5

ClpP

1.77

0.02

Transcriptional regulator

D2N576

SarX

9.91

0.01

D2N9W6

AraC family regulatory protein

4.48

0.01

D2N9P8

Phosphosugar-binding transcriptional regulator, RpiR family

3.99

0.02

D2N3I9

Transcriptional regulator, GntR family

3.32

0.02

D2N9Q7

Phosphosugar-binding transcriptional regulator

3.07

0.03

D2N823

PhoP

2.36

0.02

D2N6S6

Glycerol uptake operon antiterminator regulatory protein

2.41

0.03

D2N8K6

RecX

2.08

0.04

Arginine and proline metabolism

D2NAL7

ArcA

6.11

0.03

D2NAL6

ArcB

4.18

0.02

D2NAL4

ArcC

2.52

0.03

Multidrug resistance

D2N9T7

Multidrug resistance protein A

4.72

0.02

D2N552

Multidrug resistance ABC transporter ATP-binding and permease protein

3.84

0.02

Two-component system

D2N9Y1

NarH

2.36

0.03

D2N361

YycG

1.89

0.03

Pyrimidine metabolism

D2NAJ6

NrdD

11.84

0.02

D2N6H8

PyrE

2.36

0.02

D2N6H3

PyrB

2.11

0.04

D2N942

Upp

1.52

0.02

Pyruvate metabolism

D2N3S5

PflB

2.37

0.04

D2N9V0

Mqo

2.26

0.02

D2N7L8

AccC

1.78

0.02

Histidine metabolism

D2N9R5

HutU

17.44

0.01

D2N9R4

HutI

3.59

0.02

D2N9R7

HutG

1.82

0.04

Glycolysis/gluconeogenesis

D2NAA0

Fbp

2.63

0.02

D2N9Z9

GpmA

2.50

0.02

D2N8B5

PckA

2.34

0.02

Other known proteins

D2N3K5

CapC

21.85

0.01

D2N3F9

Antigen, 67 kDa

11.84

0.05

D2N5J2

Probable membrane protein

8.22

0.01

D2NA54

3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase)

7.79

0.01

D2N5B9

QueC

6.59

0.01

D2N3D6

Amidohydrolase 2

6.51

0.02

D2N543

Iron dependent repressor

6.42

0.02

D2N8W0

Nitroreductase family protein

6.12

0.02

D2N628

Acetyl transferase

5.96

0.02

D2NA36

Para-nitrobenzyl esterase

5.36

0.02

D2N4R9

FolP

4.83

0.02

D2N3T8

ABC transporter, substrate-binding protein

4.82

0.02

D2N549

Teichoic acid biosynthesis protein X

4.81

0.01

D2N944

UPF0340 protein

4.72

0.02

D2N4D0

Stage 0 sporulation protein J

4.54

0.01

D2N5Q4

Cytosol aminopeptidase family protein

4.53

0.04

D2N4P0

Stage 0 sporulation protein YaaT

3.98

0.02

D2N526

Hydrolase, alpha/beta hydrolase fold family

3.92

0.02

D2N723

DapB

3.80

0.02

D2N3Q0

Pts system eiibc component

3.71

0.02

D2N8G9

ABC transporter EcsB

3.67

0.01

D2N3F6

Aminoacylase

3.58

0.02

D2N585

Lipoprotein, putative

3.47

0.02

D2N6B0

SpoU rRNA Methylase family protein

3.42

0.02

D2N349

NnrD

3.39

0.02

D2NAA6

Glyoxalase family protein

3.37

0.02

D2N362

YycH protein

3.21

0.03

D2N6F0

UPF0747 protein

3.18

0.02

D2N3K2

Aldehyde-alcohol dehydrogenase 2

3.12

0.02

D2N9Q3

Phosphoglycolate phosphatase

3.04

0.02

D2N411

ABC transporter, permease protein

3.01

0.02

D2N7J1

Asppase

2.69

0.03

D2N7R6

NfeD

2.63

0.01

D2N4E3

Phosphoglycerate mutase family protein

2.59

0.02

D2N7R2

PhoH family protein

2.55

0.02

D2N5I8

Rnr

2.52

0.02

D2N7Z5

Tag

2.48

0.02

D2N9Z1

Zinc-binding lipoprotein AdcA

2.47

0.04

D2N4S0

FolB

2.41

0.04

D2N363

YycI protein

2.39

0.02

D2NA39

ABC transporter ATP-binding protein

2.36

0.04

D2N499

NAD-dependent epimerase/dehydratase

2.36

0.02

D2N6R1

PgsA

2.34

0.02

D2N5Y1

NadK

2.34

0.02

D2N804

EngB

2.18

0.02

D2N421

NanE

2.15

0.04

D2N6C3

MurI

2.12

0.02

D2N356

DHH subfamily 1 protein

2.11

0.02

D2N8M1

Map

2.10

0.02

D2N5H2

UPF0042 nucleotide-binding protein

2.10

0.03

D2N7R9

Ribosomal RNA small subunit methyltransferase E

2.10

0.01

D2N870

Ftsk/spoiiie family protein

2.09

0.02

D2N9Y2

Nitrate reductase, alpha subunit

2.04

0.02

D2N5V8

FabH

1.95

0.02

D2NA13

ABC transporter, ATP-binding/permease protein

1.92

0.04

D2N6V0

Cardiolipin synthetase (Cardiolipin synthase) (CLsynthase)

1.92

0.03

D2N6W2

Catalase

1.90

0.02

D2N8Q5

Aldehyde dehydrogenase

1.87

0.02

D2N558

DhaK

1.86

0.04

D2N9V4

TpgX protein

1.84

0.02

D2N860

Fhs

1.82

0.02

D2N8R8

Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase

1.80

0.04

D2N5D0

ABC transporter permease protein

1.80

0.04

D2N7M6

GcvPB

1.80

0.04

D2N694

Glycerophosphoryl diester phosphodiesterase

1.79

0.02

D2N634

QoxB

1.78

0.02

D2N4Q0

IspE

1.78

0.02

D2N727

LysA

1.77

0.02

D2N6R4

Rny

1.74

0.02

D2N9L2

ModA

1.71

0.03

D2N5F5

DegV family protein

1.69

0.02

D2N520

Iron-binding protein

1.66

0.04

D2N9C8

Alcohol dehydrogenase, zinc-binding domain protein

1.64

0.02

D2N359

PurA

1.64

0.04

D2N6G7

IleS

1.62

0.02

D2N9V2

TagF domain protein

1.61

0.02

D2N6Y5

Transcription antiterminator

1.60

0.04

D2N7P9

ATP-dependent RNA helicase

1.60

0.02

D2N4Q1

PurR

1.58

0.02

D2N5F8

Ribosomal subunit interface protein

1.57

0.02

D2N662

Potassium uptake protein TrkA

1.57

0.02

D2N9C5

Conserved domain protein

1.57

0.02

D2N7J7

Zwf

1.56

0.03

D2N3I0

Acetoin(Diacetyl) reductase (Acetoin dehydrogenase)

1.55

0.02

D2N780

AsnS

1.53

0.02

D2N8B2

2,5-diketo-D-gluconic acid reductase A

1.52

0.02

D2N5Q3

YumB

1.52

0.02

D2N6S5

MutL

1.52

0.03

D2N6M8

TopA

1.52

0.04

D2N523

Hydrolase, alpha/beta hydrolase fold family

1.51

0.02

D2N4S2

LysS

1.51

0.02

Unknown proteins

D2N9S7

Uncharacterized protein

9.98

0.02

D2N965

Uncharacterized protein

8.45

0.01

D2N3Y5

Uncharacterized protein

5.51

0.02

D2N899

Uncharacterized protein

4.17

0.02

D2N9W5

Uncharacterized protein

3.98

0.01

D2N4F3

Uncharacterized protein

3.92

0.03

D2N692

Uncharacterized protein

3.24

0.05

D2N5Y6

Uncharacterized protein

2.69

0.02

D2N5H8

Uncharacterized protein

2.65

0.02

D2N8E4

Uncharacterized protein

2.60

0.02

D2N678

Uncharacterized protein

2.58

0.02

D2N6V3

Uncharacterized protein

2.15

0.02

D2N9T5

Uncharacterized protein

2.07

0.04

D2N8T9

Uncharacterized protein

2.03

0.04

D2N8R7

Uncharacterized protein

1.89

0.02

D2N8B3

Uncharacterized protein

1.65

0.02

D2N6R0

Uncharacterized protein

1.64

0.03

D2N9C6

Uncharacterized protein

1.58

0.02

D2N971

Uncharacterized protein

1.56

0.02

D2N5K3

Uncharacterized protein

1.67

0.03

  1. *The calculation of FC (398/239) in this table is dividing the average value of peptide mass of proteins in ST398 strains by that average value in ST239 strains
  2. **Bold italics in this table is used to highlight the selected significantly differentially expressed genes for CA-SA ST398 up-regulated network construction