Skip to main content

Table 1 Proteins significantly up-regulated in poor responder patients as indicated in the volcano plot

From: Proteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases

Acc. Nr.

Protein name

Gene name

log2 fold change (t-test difference)

p value

t-test significant

Eukaryotic translation initiation factors (EIFs)

Q14232

Translation initiation factor eIF-2B subunit alpha

EIF2B1

1.04

2.48E − 03

 

Q14152

Eukaryotic translation initiation factor 3 subunit A

EIF3A

1.13

5.71E − 03

 

P55884

Eukaryotic translation initiation factor 3 subunit B

EIF3B

1.57

3.62E − 03

 

O00303

Eukaryotic translation initiation factor 3 subunit F

EIF3F

1.23

9.41E − 03

 

O75821

Eukaryotic translation initiation factor 3 subunit G

EIF3G

1.59

4.81E − 02

 

Q13347

Eukaryotic translation initiation factor 3 subunit I

EIF3I

2.88

4.29E − 05

*

Q9UBQ5

Eukaryotic translation initiation factor 3 subunit K

EIF3 K

1.85

3.50E − 05

 

Q9Y262

Eukaryotic translation initiation factor 3 subunit L

EIF3L

1.57

7.30E − 03

 

P23588

Eukaryotic translation initiation factor 4B

EIF4B

1.69

1.44E − 03

 

Q15056

Eukaryotic translation initiation factor 4H

EIF4H

1.68

3.92E − 04

 

O60841

Eukaryotic translation initiation factor 5B

EIF5B

1.26

2.53E − 02

 

Neuronal proteins

Q8N111

Cell cycle exit and neuronal differentiation protein 1

CEND1

2.86

1.98E − 03

 

P51674

Neuronal membrane glycoprotein M6-a

GPM6A

5.30

5.24E − 05

*

P62166

Neuronal calcium sensor 1

NCS1

3.55

6.65E − 05

*

Q7Z3B1

Neuronal growth regulator 1

NEGR1

3.71

1.93E − 03

 

Q15818

Neuronal pentraxin-1

NPTX1

3.07

4.79E − 03

 

Q92823

Neuronal cell adhesion molecule

NRCAM

2.44

3.48E − 03

 

Q9UH03

Neuronal-specific septin-3

SEPT3

3.40

3.68E − 04

 

P17600

Synapsin-1

SYN1

4.68

2.47E − 04

*

Q92777

Synapsin-2

SYN2

5.49

3.17E − 04

*

O14994

Synapsin-3

SYN3

2.46

5.70E − 03

 

Transporter proteins

P30531

Sodium- and chloride-dependent GABA transporter 1

SLC6A1

3.44

8.85E − 06

*

P43003

Excitatory amino acid transporter 1

SLC1A3

3.17

2.51E − 03

 

P43004

Excitatory amino acid transporter 2

SLC1A2

4.98

5.16E − 03

 

P43007

Neutral amino acid transporter A

SLC1A4

1.81

4.10E − 02

 

P48066

Sodium- and chloride-dependent GABA transporter 3

SLC6A11

2.12

4.95E − 04

 

Q15043

Zinc transporter ZIP14

SLC39A14

1.28

3.30E − 03

 

Q6PML9

Zinc transporter 9

SLC30A9

1.57

1.36E − 02

 

Q8N4V1

Membrane magnesium transporter 1

MMGT1

1.19

3.22E − 02

 

Q8TBB6

Probable cationic amino acid transporter

SLC7A14

1.78

6.86E − 03

 

Q96QE2

Proton myo-inositol cotransporter

SLC2A13

2.68

1.94E − 06

*

Q99726

Zinc transporter 3

SLC30A3

2.03

2.95E − 02

 

Q9H1V8

Sodium-dependent neutral amino acid transporter SLC6A17

SLC6A17

2.51

1.39E − 02

 

Q9NS82

Asc-type amino acid transporter 1

SLC7A10

1.44

6.39E − 03

 

Exchanger proteins

P32418

Sodium/calcium exchanger 1

SLC8A1

1.66

4.06E − 02

 

Q8TCU6

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

PREX1

1.03

1.03E − 03

 

Q92581

Sodium/hydrogen exchanger 6

SLC9A6

1.76

9.73E − 03

 

Q9UPR5

Sodium/calcium exchanger 2

SLC8A2

4.39

1.18E − 03

 

V-type proton ATPases

Q15904

V-type proton ATPase subunit S1

ATP6AP1

1.41

3.12E − 02

 

Q93050

V-type proton ATPase 116 kDa subunit a isoform 1

ATP6V0A1

2.57

2.75E − 04

 

P27449

V-type proton ATPase 16 kDa proteolipid subunit

ATP6V0C

2.36

5.37E − 03

 

P61421

V-type proton ATPase subunit d 1

ATP6V0D1

3.96

8.92E − 07

*

P38606

V-type proton ATPase catalytic subunit A

ATP6V1A

1.82

6.37E − 05

 

P21281

V-type proton ATPase subunit B, brain isoform

ATP6V1B2

1.62

2.37E − 04

 

P21283

V-type proton ATPase subunit C 1

ATP6V1C1

1.51

5.27E − 05

 

Q9Y5K8

V-type proton ATPase subunit D

ATP6V1D

2.19

5.15E − 04

 

P36543

V-type proton ATPase subunit E 1

ATP6V1E1

1.27

6.60E − 04

 

Q16864

V-type proton ATPase subunit F

ATP6V1F

3.12

5.47E − 07

*

O75348

V-type proton ATPase subunit G 1

ATP6V1G1

2.39

5.16E − 04

 

O95670

V-type proton ATPase subunit G 2

ATP6V1G2

1.40

4.11E − 04

 

Q9UI12

V-type proton ATPase subunit H

ATP6V1H

2.75

4.83E − 04

 

MAP-kinases

P28482

Mitogen-activated protein kinase 1

MAPK1

1.78

6.70E − 04

 

P53779

Mitogen-activated protein kinase 10

MAPK10

2.27

1.27E − 03

 

P27361

Mitogen-activated protein kinase 3

MAPK3

1.79

1.39E − 03

 

Q9UPT6

C-Jun-amino-terminal kinase-interacting protein 3

MAPK8IP3

2.21

1.83E − 03

 

Cell adhesion proteins

O00533

Neural cell adhesion molecule L1-like protein

CHL1

1.59

3.85E − 02

 

O15394

Neural cell adhesion molecule 2

NCAM2

2.56

1.84E − 02

 

P13591

Neural cell adhesion molecule 1

NCAM1

3.72

1.12E − 04

*

P32004

Neural cell adhesion molecule L1

L1CAM

4.27

1.91E − 06

*

Q14982

Opioid-binding protein/cell adhesion molecule

OPCML

4.53

7.99E − 04

*

Q14CZ8

Hepatocyte cell adhesion molecule

HEPACAM

2.49

1.23E − 02

 

Q8N3J6

Cell adhesion molecule 2

CADM2

4.32

1.24E − 03

 

Q8NFZ8

Cell adhesion molecule 4

CADM4

1.74

2.53E − 02

 

Q92823

Neuronal cell adhesion molecule

NRCAM

2.44

3.48E − 03

 

Calcium-ion binding proteins

P62158

Calmodulin

CALM1

1.36

9.22E − 06

 

Q14012

Calcium/calmodulin-dependent protein kinase type 1

CAMK1

2.17

4.56E − 04

 

Q9UQM7

Calcium/calmodulin-dependent protein kinase type II subunit alpha

CAMK2A

3.00

5.85E − 04

 

Q13554

Calcium/calmodulin-dependent protein kinase type II subunit beta

CAMK2B

3.98

2.08E − 03

 

Q13555

Calcium/calmodulin-dependent protein kinase type II subunit gamma

CAMK2G

2.77

5.24E − 03

 

Q16566

Calcium/calmodulin-dependent protein kinase type IV

CAMK4

1.98

1.25E − 02

 

Q8N5S9

Calcium/calmodulin-dependent protein kinase kinase 1

CAMKK1

2.13

8.09E − 03

 

Q96RR4

Calcium/calmodulin-dependent protein kinase kinase 2

CAMKK2

2.03

8.67E − 03

 

Q9P1Y5

Calmodulin-regulated spectrin-associated protein 3

CAMSAP3

2.35

8.13E − 03

 

P54750

Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1A

PDE1A

1.97

5.00E − 03

 

Q01064

Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B

PDE1B

2.54

1.25E − 02

 

EMT

P19022

Cadherin-2

CDH2

2.53

1.02E − 03

 
  1. The table shows UniProt accession number (Acc. Nr.), protein name, gene name, t-test difference between LFQ values of poor and good responding patients (fold change, logarithmic scale to the base of two) with corresponding p values and t-test significance (rows with a t-test result above s0 = 0.5 and FDR 0.01 are reported as significant)
Back to article page

Clinical Proteomics

ISSN: 1559-0275