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Table 2 Surgical treatment and complications

From: The response to neoadjuvant chemoradiotherapy with 5-fluorouracil in locally advanced rectal cancer patients: a predictive proteomic signature

Characteristics

All patients

23 (100%)a

NR

7 (30%)

PR

10 (43%)

TR

6 (26%)

p valueb

Radiotherapy

    

0.822

 45 Gy

1 (4)

0

1 (10)

0

 

 45 Gy + 5.4 Gy

21 (91)

6 (86)

9 (90)

6 (100)

 

 50.5 Gy

1 (4)

1 (14)

0

0

 

Chemotherapy

    

3.2e−05

 Xeloda®

22 (96)

7 (100)

9 (90)

6 (100)

 

 5-FU

1 (4)

0

1 (10)

0

 

Radiodermatitis

    

0.962

 −

7 (30)

2 (29)

3 (30)

2 (33)

 

 Non-severe

13 (57)

4 (57)

5 (50)

4 (67)

 

 Severe

3 (13)

1 (14)

2 (20)

0

 

Proctitis

    

0.211

 +

11 (48)

2 (29)

7 (70)

2 (33)

 

 −

12 (52)

5 (71)

3 (30)

4 (67)

 

Colitis

    

1

 +

0

0

0

0

 

 −

23 (100)

7 (100)

10 (100)

6 (100)

 

Mucositis

    

1

 +

0

0

0

0

 

 −

23 (100)

7 (100)

10 (100)

6 (100)

 

Surgical resection type

    

0.004

 Low anterior

17 (74)

7 (100)

8 (80)

2 (33)

 

 Abdomino-perineal

2 (9)

0

2 (20)

0

 

 Endo-anal

1 (4)

0

0

1 (17)

 

 Refused

3 (13)

0

0

3 (50)

 

Surgery delay

     

 Median

8.6 ± 2.8

9.3 ± 2.7

8.3 ± 3.1

8.1 ± 2.6

 

 Range

1.4–13.1

5.3–13.1

1.4–12.9

6.0–11.0

 
  1. 5-FU 5-fluorouracil, Gy Gray, NR non-responders, PR partial responders, TR total responders
  2. aFirst number: number of patients; number in parentheses: percentage of patients
  3. bThe p value is obtained by Fisher’s exact test and is considered significant when p value < 0.05