Fig. 9

Validation of HOOK1 and PTPN6 as potential biomarker targets by western blot. A total of 19 pancreatic cyst fluid samples were analyzed by western blot to validate the relative abundance of HOOK1 and PTPN6. The immunoblotting results were consistent with our MS results. a HOOK1 was overexpressed in high-risk IPMN in the proteomic (p value < 0.001) and western blot analyses (p value < 0.01). b PTPN6 was overexpressed in high-risk IPMN in the proteomic (p value < 0.001) and western blot analyses (p value < 0.05) (*<p value 0.05, **<p value 0.01, ***<p value 0.001, ****<p value 0.0001, NS not significant, INV invasive IPMN)