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Table 3 Absolute quantification of individual sample

From: Comprehensive proteome analysis of nasal lavage samples after controlled exposure to welding nanoparticles shows an induced acute phase and a nuclear receptor, LXR/RXR, activation that influence the status of the extracellular matrix

Protein Mean slope in NL Mean slope in MilliQ water LOD (fmol/µL) Exposure Mean; median; (max–min) concentration (fmol/µL) Statistical evaluation
Before exposure After exposure Day after exposure Beta-value 95% CI p value
MMP9 0.291 0.275 0.043 A 0.26; 0.14; (0.02–0.61) 0.14; 0.13; (0.02–0.37) 0.19; 0.13; (0.02–0.36) 0.77 0.63–0.93 0.015
B 0.16; 0.15; (0.02–0.42) 0.16; 0.11 (0.03–0.52) 0.18; 0.16; (0.08–0.4)    
A1AT 0.153 0.158 0.205 A 0.51; 0.37; (0.23–1.28) 0.50; 0.37; (0.23–1.6) 0.44; 0.52; (0.14–0.94) 1.20 0.77–1.87 0.369
B 0.67; 0.51; (0.3–2.12) 0.52; 0.41; (0.21–1.84) 0.56; 0.45; (0.2–1.48)    
A2 MG 0.184 0.153 0.075 A 0.52; 0.43; (0.09–0.13) 0.42; 0.20; (0.08–1.32) 0.35; 0.29; (0.05–0.95) 0.95 0.73–1.23 0.669
     B 0.49; 0.32; (0.16–1.13) 0.47; 0.24; (0.09–1.55) 0.48; 0.51; (0.11–1.44)    
APOB 0.164 0.177 0.356 A/B NA NA NA
Elastin 0.432* 0.339 0.339 A/B NA NA NA
  1. Mean slope of the calibration curve for each quantitative protein and the calculated LOD (determined from blank samples)
  2. NL nasal lavage, A welding fume particle exposure, B filtered air exposure, NA no quantitative data could be obtained
  3. * Big variation between the slopes