Comprehensive proteome analysis of nasal lavage samples after controlled exposure to welding nanoparticles shows an induced acute phase and a nuclear receptor, LXR/RXR, activation that influence the status of the extracellular matrix

Table 4 Pathways associated with welding fume exposure

Symbol	Protein	AC	Expr. fold change	Expected
LXR/RXR activation (positive z-score 1.26)
AMBP	Alpha-1-microglobulin/bikunin precursor	P02760	1.23	Up
APOA4	Apolipoprotein A4	P06727	− 1.41	Up
APOH	Apolipoprotein H	P02749	− 1.54	Up
CLU	Clusterin	P10909	1.19	Up
HPX	Hemopexin	P02790	1.26	Up
IL1RN	Interleukin 1 receptor antagonist	P18510	1.30	Down
MMP9	Matrix metallopeptidase 9	P14780	− 1.29	Down
PON1	Paraoxonase 1	P27169	1.20	Up
SAA1	Serum amyloid A1	P0DJI8	1.28	Up
TTR	Transthyretin	P02766	1.38	Up
Acute phase response signaling (positive z-score 0.378)
A2M	Alpha-2-macroglobulin	P01023	1.27	Up
AMBP	Alpha-1-microglobulin/bikunin precursor	P02760	1.23	Down
APOH	Apolipoprotein H	P02749	− 1.54	Down
FN1	Fibronectin 1	P02751	− 1.25	Up
HPX	Hemopexin	P02790	1.26	Up
IL1RN	Interleukin 1 receptor antagonist	P18510	1.30	Up
SAA1	Serum amyloid A1	P0DJI8	1.28
SERPING1	Serpin family G member 1	P05155	1.24
TTR	Transthyretin	P02766	1.38	Down

The significantly changed proteins found with the LMM statistical method showed that these canonical pathways were activated due to welding fume exposure. AC: accession number. Expected: The changed direction of the protein for this canonical pathway to be activated are expected to go in e certain direction when its activated

ISSN: 1559-0275