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Table 4 Pathways associated with welding fume exposure

From: Comprehensive proteome analysis of nasal lavage samples after controlled exposure to welding nanoparticles shows an induced acute phase and a nuclear receptor, LXR/RXR, activation that influence the status of the extracellular matrix

Symbol Protein AC Expr. fold change Expected
LXR/RXR activation (positive z-score 1.26)
AMBP Alpha-1-microglobulin/bikunin precursor P02760 1.23 Up
APOA4 Apolipoprotein A4 P06727 − 1.41 Up
APOH Apolipoprotein H P02749 − 1.54 Up
CLU Clusterin P10909 1.19 Up
HPX Hemopexin P02790 1.26 Up
IL1RN Interleukin 1 receptor antagonist P18510 1.30 Down
MMP9 Matrix metallopeptidase 9 P14780 − 1.29 Down
PON1 Paraoxonase 1 P27169 1.20 Up
SAA1 Serum amyloid A1 P0DJI8 1.28 Up
TTR Transthyretin P02766 1.38 Up
Acute phase response signaling (positive z-score 0.378)
A2M Alpha-2-macroglobulin P01023 1.27 Up
AMBP Alpha-1-microglobulin/bikunin precursor P02760 1.23 Down
APOH Apolipoprotein H P02749 − 1.54 Down
FN1 Fibronectin 1 P02751 − 1.25 Up
HPX Hemopexin P02790 1.26 Up
IL1RN Interleukin 1 receptor antagonist P18510 1.30 Up
SAA1 Serum amyloid A1 P0DJI8 1.28  
SERPING1 Serpin family G member 1 P05155 1.24  
TTR Transthyretin P02766 1.38 Down
  1. The significantly changed proteins found with the LMM statistical method showed that these canonical pathways were activated due to welding fume exposure. AC: accession number. Expected: The changed direction of the protein for this canonical pathway to be activated are expected to go in e certain direction when its activated